Mp2g07580.1

Protein

Length

389 amino acids

Protein family membership

None predicted.

Homologous superfamilies

Homologous superfamily
119 - 322
NAD(P)-binding domain superfamily (IPR036291)

1 50 100 150 200 250 300 350 389

Domains and repeats

Domain
30 - 345
D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain (IPR006139)
Domain
128 - 321
D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain (IPR006140)

1 50 100 150 200 250 300 350 389

Detailed signature matches

IPR036291

NAD(P)-binding domain superfamily
1. SSF51735 (NAD(P)-bi...)
  
  119 - 322
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR006139

D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
1. PF00389 (2-Hacid_dh)
  
  30 - 127
  
  Pfam
  PF00389 (2-Hacid_dh)
  
  322 - 345
  
  Pfam
  PF00389 (2-Hacid_dh)
IPR006140

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
1. PF02826 (2-Hacid_dh_C)
  
  128 - 321
  
  Pfam
  PF02826 (2-Hacid_dh_C)
IPR029752

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1
1. PS00065 (D_2_HYDROX...)
  
  167 - 195
  
  PROSITE patterns
  PS00065 (D_2_HYDROXYACID_DH_1)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

117 - 320

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)

20 - 116

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)

321 - 345

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
PTHR10996 (2-HYDROX...)

28 - 369

PANTHER
PTHR10996 (2-HYDROXYACID DEHYDROGENASE-RELATED)
PTHR10996:SF257 (ZG...)

28 - 369

PANTHER
PTHR10996:SF257 (ZGC:136493)
SSF52283 (Formate/g...)

15 - 155

SUPERFAMILY
SSF52283 (Formate/glycerate dehydrogenase catalytic domain-like)
cd05301 (GDH)

16 - 345

CDD
cd05301 (GDH)

Residue annotation

dimerization inter...

21K

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

22P

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

24P

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

68Q

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

69L

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

70T

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

92M

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

120E

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

121T

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

124E

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

125L

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

127A

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

128A

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

131L

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

135R

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

137V

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

145R

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

147G

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

149Y

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

151G

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

152W

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

153L

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

154P

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

155N

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

156L

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

157F

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

159G

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

160N

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

161L

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

162L

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

163K

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

181R

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

182M

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

186G

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

187F

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

301E

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

302P

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

309G

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

315V

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

316V

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

317V

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

318P

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

319H

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

320I

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

321A

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

323A

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

324S

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

325K

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

326W

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)

328R

dimerization interface
21K, 22P, 24P, 68Q, 69L, 70T, 92M, 120E, 121T, 124E, 125L, 127A, 128A, 131L, 135R, 137V, 145R, 147G, 149Y, 151G, 152W, 153L, 154P, 155N, 156L, 157F, 159G, 160N, 161L, 162L, 163K, 181R, 182M, 186G, 187F, 301E, 302P, 309G, 315V, 316V, 317V, 318P, 319H, 320I, 321A, 323A, 324S, 325K, 326W, 328R
CDD
cd05301 (GDH)
ligand binding sit...

69L

ligand binding site
69L, 93A, 94V, 95G, 118L, 272R, 319H, 322S
CDD
cd05301 (GDH)

93A

ligand binding site
69L, 93A, 94V, 95G, 118L, 272R, 319H, 322S
CDD
cd05301 (GDH)

94V

ligand binding site
69L, 93A, 94V, 95G, 118L, 272R, 319H, 322S
CDD
cd05301 (GDH)

95G

ligand binding site
69L, 93A, 94V, 95G, 118L, 272R, 319H, 322S
CDD
cd05301 (GDH)

118L

ligand binding site
69L, 93A, 94V, 95G, 118L, 272R, 319H, 322S
CDD
cd05301 (GDH)

272R

ligand binding site
69L, 93A, 94V, 95G, 118L, 272R, 319H, 322S
CDD
cd05301 (GDH)

319H

ligand binding site
69L, 93A, 94V, 95G, 118L, 272R, 319H, 322S
CDD
cd05301 (GDH)

322S

ligand binding site
69L, 93A, 94V, 95G, 118L, 272R, 319H, 322S
CDD
cd05301 (GDH)
NADP binding site ...

94V

NADP binding site
94V, 95G, 122T, 171G, 172A, 173G, 174R, 175I, 194Y, 195D, 196L, 199S, 242H, 243P, 244V, 248T, 249T, 270A, 271S, 272R, 296D, 297V, 319H, 321A, 322S
CDD
cd05301 (GDH)

95G

NADP binding site
94V, 95G, 122T, 171G, 172A, 173G, 174R, 175I, 194Y, 195D, 196L, 199S, 242H, 243P, 244V, 248T, 249T, 270A, 271S, 272R, 296D, 297V, 319H, 321A, 322S
CDD
cd05301 (GDH)

122T

NADP binding site
94V, 95G, 122T, 171G, 172A, 173G, 174R, 175I, 194Y, 195D, 196L, 199S, 242H, 243P, 244V, 248T, 249T, 270A, 271S, 272R, 296D, 297V, 319H, 321A, 322S
CDD
cd05301 (GDH)

171G

NADP binding site
94V, 95G, 122T, 171G, 172A, 173G, 174R, 175I, 194Y, 195D, 196L, 199S, 242H, 243P, 244V, 248T, 249T, 270A, 271S, 272R, 296D, 297V, 319H, 321A, 322S
CDD
cd05301 (GDH)

172A

NADP binding site
94V, 95G, 122T, 171G, 172A, 173G, 174R, 175I, 194Y, 195D, 196L, 199S, 242H, 243P, 244V, 248T, 249T, 270A, 271S, 272R, 296D, 297V, 319H, 321A, 322S
CDD
cd05301 (GDH)

173G

NADP binding site
94V, 95G, 122T, 171G, 172A, 173G, 174R, 175I, 194Y, 195D, 196L, 199S, 242H, 243P, 244V, 248T, 249T, 270A, 271S, 272R, 296D, 297V, 319H, 321A, 322S
CDD
cd05301 (GDH)

174R

NADP binding site
94V, 95G, 122T, 171G, 172A, 173G, 174R, 175I, 194Y, 195D, 196L, 199S, 242H, 243P, 244V, 248T, 249T, 270A, 271S, 272R, 296D, 297V, 319H, 321A, 322S
CDD
cd05301 (GDH)

175I

NADP binding site
94V, 95G, 122T, 171G, 172A, 173G, 174R, 175I, 194Y, 195D, 196L, 199S, 242H, 243P, 244V, 248T, 249T, 270A, 271S, 272R, 296D, 297V, 319H, 321A, 322S
CDD
cd05301 (GDH)

194Y

NADP binding site
94V, 95G, 122T, 171G, 172A, 173G, 174R, 175I, 194Y, 195D, 196L, 199S, 242H, 243P, 244V, 248T, 249T, 270A, 271S, 272R, 296D, 297V, 319H, 321A, 322S
CDD
cd05301 (GDH)

195D

NADP binding site
94V, 95G, 122T, 171G, 172A, 173G, 174R, 175I, 194Y, 195D, 196L, 199S, 242H, 243P, 244V, 248T, 249T, 270A, 271S, 272R, 296D, 297V, 319H, 321A, 322S
CDD
cd05301 (GDH)

196L

NADP binding site
94V, 95G, 122T, 171G, 172A, 173G, 174R, 175I, 194Y, 195D, 196L, 199S, 242H, 243P, 244V, 248T, 249T, 270A, 271S, 272R, 296D, 297V, 319H, 321A, 322S
CDD
cd05301 (GDH)

199S

NADP binding site
94V, 95G, 122T, 171G, 172A, 173G, 174R, 175I, 194Y, 195D, 196L, 199S, 242H, 243P, 244V, 248T, 249T, 270A, 271S, 272R, 296D, 297V, 319H, 321A, 322S
CDD
cd05301 (GDH)

242H

NADP binding site
94V, 95G, 122T, 171G, 172A, 173G, 174R, 175I, 194Y, 195D, 196L, 199S, 242H, 243P, 244V, 248T, 249T, 270A, 271S, 272R, 296D, 297V, 319H, 321A, 322S
CDD
cd05301 (GDH)

243P

NADP binding site
94V, 95G, 122T, 171G, 172A, 173G, 174R, 175I, 194Y, 195D, 196L, 199S, 242H, 243P, 244V, 248T, 249T, 270A, 271S, 272R, 296D, 297V, 319H, 321A, 322S
CDD
cd05301 (GDH)

244V

NADP binding site
94V, 95G, 122T, 171G, 172A, 173G, 174R, 175I, 194Y, 195D, 196L, 199S, 242H, 243P, 244V, 248T, 249T, 270A, 271S, 272R, 296D, 297V, 319H, 321A, 322S
CDD
cd05301 (GDH)

248T

NADP binding site
94V, 95G, 122T, 171G, 172A, 173G, 174R, 175I, 194Y, 195D, 196L, 199S, 242H, 243P, 244V, 248T, 249T, 270A, 271S, 272R, 296D, 297V, 319H, 321A, 322S
CDD
cd05301 (GDH)

249T

NADP binding site
94V, 95G, 122T, 171G, 172A, 173G, 174R, 175I, 194Y, 195D, 196L, 199S, 242H, 243P, 244V, 248T, 249T, 270A, 271S, 272R, 296D, 297V, 319H, 321A, 322S
CDD
cd05301 (GDH)

270A

NADP binding site
94V, 95G, 122T, 171G, 172A, 173G, 174R, 175I, 194Y, 195D, 196L, 199S, 242H, 243P, 244V, 248T, 249T, 270A, 271S, 272R, 296D, 297V, 319H, 321A, 322S
CDD
cd05301 (GDH)

271S

NADP binding site
94V, 95G, 122T, 171G, 172A, 173G, 174R, 175I, 194Y, 195D, 196L, 199S, 242H, 243P, 244V, 248T, 249T, 270A, 271S, 272R, 296D, 297V, 319H, 321A, 322S
CDD
cd05301 (GDH)

272R

NADP binding site
94V, 95G, 122T, 171G, 172A, 173G, 174R, 175I, 194Y, 195D, 196L, 199S, 242H, 243P, 244V, 248T, 249T, 270A, 271S, 272R, 296D, 297V, 319H, 321A, 322S
CDD
cd05301 (GDH)

296D

NADP binding site
94V, 95G, 122T, 171G, 172A, 173G, 174R, 175I, 194Y, 195D, 196L, 199S, 242H, 243P, 244V, 248T, 249T, 270A, 271S, 272R, 296D, 297V, 319H, 321A, 322S
CDD
cd05301 (GDH)

297V

NADP binding site
94V, 95G, 122T, 171G, 172A, 173G, 174R, 175I, 194Y, 195D, 196L, 199S, 242H, 243P, 244V, 248T, 249T, 270A, 271S, 272R, 296D, 297V, 319H, 321A, 322S
CDD
cd05301 (GDH)

319H

NADP binding site
94V, 95G, 122T, 171G, 172A, 173G, 174R, 175I, 194Y, 195D, 196L, 199S, 242H, 243P, 244V, 248T, 249T, 270A, 271S, 272R, 296D, 297V, 319H, 321A, 322S
CDD
cd05301 (GDH)

321A

NADP binding site
94V, 95G, 122T, 171G, 172A, 173G, 174R, 175I, 194Y, 195D, 196L, 199S, 242H, 243P, 244V, 248T, 249T, 270A, 271S, 272R, 296D, 297V, 319H, 321A, 322S
CDD
cd05301 (GDH)

322S

NADP binding site
94V, 95G, 122T, 171G, 172A, 173G, 174R, 175I, 194Y, 195D, 196L, 199S, 242H, 243P, 244V, 248T, 249T, 270A, 271S, 272R, 296D, 297V, 319H, 321A, 322S
CDD
cd05301 (GDH)

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

Cellular Component