Mp3g07970.1

Protein

Length

2,065 amino acids

Protein family membership

None predicted.

Homologous superfamilies

Homologous superfamily
806 - 940
Aspartic peptidase domain superfamily (IPR021109)
1,172 - 1,610
DNA/RNA polymerase superfamily (IPR043502)
1,770 - 1,967
Ribonuclease H superfamily (IPR036397)
Homologous superfamily
1,276 - 1,410
Reverse transcriptase/Diguanylate cyclase domain (IPR043128)
1,425 - 1,623
Reverse transcriptase/Diguanylate cyclase domain (IPR043128)
1,776 - 1,929
Ribonuclease H-like superfamily (IPR012337)

1 200 400 600 800 1000 1200 1400 1600 1800 2065

Domains and repeats

Domain
176 - 265
Retrotransposon gag domain (IPR005162)
1,251 - 1,399
Reverse transcriptase domain (IPR000477)
1,473 - 1,572
Reverse transcriptase/retrotransposon-derived protein, RNase H-like domain (IPR041577)
1,707 - 1,761
Integrase zinc-binding domain (IPR041588)
1,775 - 1,935
Integrase, catalytic core (IPR001584)

1 200 400 600 800 1000 1200 1400 1600 1800 2065

Detailed signature matches

IPR021109

Aspartic peptidase domain superfamily
1. G3DSA:2.40.70.10 (A...)
  
  806 - 940
  
  GENE3D
  G3DSA:2.40.70.10 (Acid Proteases)
2. SSF50630 (Acid prot...)
  
  830 - 929
  
  SUPERFAMILY
  SSF50630 (Acid proteases)
IPR043502

DNA/RNA polymerase superfamily
1. SSF56672 (DNA/RNA p...)
  
  1,172 - 1,610
  
  SUPERFAMILY
  SSF56672 (DNA/RNA polymerases)
IPR043128

Reverse transcriptase/Diguanylate cyclase domain
1. G3DSA:3.30.70...
  
  1,337 - 1,410
  
  GENE3D
  G3DSA:3.30.70.270 (G3DSA:3.30.70.270)
  
  1,276 - 1,303
  
  GENE3D
  G3DSA:3.30.70.270 (G3DSA:3.30.70.270)
  
  1,425 - 1,494
  
  GENE3D
  G3DSA:3.30.70.270 (G3DSA:3.30.70.270)
  
  1,611 - 1,623
  
  GENE3D
  G3DSA:3.30.70.270 (G3DSA:3.30.70.270)
IPR036397

Ribonuclease H superfamily
1. G3DSA:3.30.42...
  
  1,770 - 1,967
  
  GENE3D
  G3DSA:3.30.420.10 (G3DSA:3.30.420.10)
IPR012337

Ribonuclease H-like superfamily
1. SSF53098 (Ribonucle...)
  
  1,776 - 1,929
  
  SUPERFAMILY
  SSF53098 (Ribonuclease H-like)
IPR005162

Retrotransposon gag domain
1. PF03732 (Retrotrans...)
  
  176 - 265
  
  Pfam
  PF03732 (Retrotrans_gag)
IPR000477

Reverse transcriptase domain
1. PF00078 (RVT_1)
  
  1,251 - 1,399
  
  Pfam
  PF00078 (RVT_1)
IPR041577

Reverse transcriptase/retrotransposon-derived protein, RNase H-like domain
1. PF17919 (RT_RNaseH_2)
  
  1,473 - 1,572
  
  Pfam
  PF17919 (RT_RNaseH_2)
IPR041588

Integrase zinc-binding domain
1. PF17921 (Integrase_...)
  
  1,707 - 1,761
  
  Pfam
  PF17921 (Integrase_H2C2)
IPR001584

Integrase, catalytic core
1. PF00665 (rve)
  
  1,779 - 1,876
  
  Pfam
  PF00665 (rve)
2. PS50994 (INTEGRASE)
  
  1,775 - 1,935
  
  PROSITE profiles
  PS50994 (INTEGRASE)

no IPR

Unintegrated signatures

G3DSA:1.10.34...

1,671 - 1,761

GENE3D
G3DSA:1.10.340.70 (G3DSA:1.10.340.70)
G3DSA:3.10.10.10 (H...)

1,304 - 1,336

GENE3D
G3DSA:3.10.10.10 (HIV Type 1 Reverse Transcriptase)

1,195 - 1,275

GENE3D
G3DSA:3.10.10.10 (HIV Type 1 Reverse Transcriptase)
G3DSA:3.10.20...

1,495 - 1,610

GENE3D
G3DSA:3.10.20.370 (G3DSA:3.10.20.370)
PTHR24559 (TRANSPOS...)

1,207 - 1,942

PANTHER
PTHR24559 (TRANSPOSON TY3-I GAG-POL POLYPROTEIN)
PTHR24559:SF324 (TR...)

1,207 - 1,942

PANTHER
PTHR24559:SF324 (TRANSPOSON TY3-I GAG-POL POLYPROTEIN-LIKE PROTEIN)
cd00303 (retropepsi...)

839 - 922

CDD
cd00303 (retropepsin_like)
cd01647 (RT_LTR)

1,234 - 1,410

CDD
cd01647 (RT_LTR)
cd09274 (RNase_HI_R...)

1,504 - 1,624

CDD
cd09274 (RNase_HI_RT_Ty3)

Other features

Coil

695 - 715

COILS
Coil (Coil)
mobidb-lite (disord...)

523 - 639

MobiDB Lite
mobidb-lite (disorder_prediction)

722 - 745

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 36

MobiDB Lite
mobidb-lite (disorder_prediction)
mobidb-lite (Polyam...)

722 - 736

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polyampholyte
mobidb-lite (Polar)

559 - 573

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

579 - 627

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

Residue annotation

Catalytic residue ...

842D

Catalytic residue
842D
CDD
cd00303 (retropepsin_like)
catalytic motif cd...

842D

catalytic motif
842D, 843G, 844G
CDD
cd00303 (retropepsin_like)

843G

catalytic motif
842D, 843G, 844G
CDD
cd00303 (retropepsin_like)

844G

catalytic motif
842D, 843G, 844G
CDD
cd00303 (retropepsin_like)
inhibitor binding ...

842D

inhibitor binding site
842D, 844G, 846G, 870I, 871N, 872M, 915L
CDD
cd00303 (retropepsin_like)

844G

inhibitor binding site
842D, 844G, 846G, 870I, 871N, 872M, 915L
CDD
cd00303 (retropepsin_like)

846G

inhibitor binding site
842D, 844G, 846G, 870I, 871N, 872M, 915L
CDD
cd00303 (retropepsin_like)

870I

inhibitor binding site
842D, 844G, 846G, 870I, 871N, 872M, 915L
CDD
cd00303 (retropepsin_like)

871N

inhibitor binding site
842D, 844G, 846G, 870I, 871N, 872M, 915L
CDD
cd00303 (retropepsin_like)

872M

inhibitor binding site
842D, 844G, 846G, 870I, 871N, 872M, 915L
CDD
cd00303 (retropepsin_like)

915L

inhibitor binding site
842D, 844G, 846G, 870I, 871N, 872M, 915L
CDD
cd00303 (retropepsin_like)
Active site flap c...

870I

Active site flap
870I, 871N, 872M, 873A, 877S, 878A, 879V, 880P
CDD
cd00303 (retropepsin_like)

871N

Active site flap
870I, 871N, 872M, 873A, 877S, 878A, 879V, 880P
CDD
cd00303 (retropepsin_like)

872M

Active site flap
870I, 871N, 872M, 873A, 877S, 878A, 879V, 880P
CDD
cd00303 (retropepsin_like)

873A

Active site flap
870I, 871N, 872M, 873A, 877S, 878A, 879V, 880P
CDD
cd00303 (retropepsin_like)

877S

Active site flap
870I, 871N, 872M, 873A, 877S, 878A, 879V, 880P
CDD
cd00303 (retropepsin_like)

878A

Active site flap
870I, 871N, 872M, 873A, 877S, 878A, 879V, 880P
CDD
cd00303 (retropepsin_like)

879V

Active site flap
870I, 871N, 872M, 873A, 877S, 878A, 879V, 880P
CDD
cd00303 (retropepsin_like)

880P

Active site flap
870I, 871N, 872M, 873A, 877S, 878A, 879V, 880P
CDD
cd00303 (retropepsin_like)
putative NTP bindi...

1,298D

putative NTP binding site
1,298D, 1,299G, 1,300Y, 1,301S, 1,302G, 1,303Y, 1,332F, 1,362D
CDD
cd01647 (RT_LTR)

1,299G

putative NTP binding site
1,298D, 1,299G, 1,300Y, 1,301S, 1,302G, 1,303Y, 1,332F, 1,362D
CDD
cd01647 (RT_LTR)

1,300Y

putative NTP binding site
1,298D, 1,299G, 1,300Y, 1,301S, 1,302G, 1,303Y, 1,332F, 1,362D
CDD
cd01647 (RT_LTR)

1,301S

putative NTP binding site
1,298D, 1,299G, 1,300Y, 1,301S, 1,302G, 1,303Y, 1,332F, 1,362D
CDD
cd01647 (RT_LTR)

1,302G

putative NTP binding site
1,298D, 1,299G, 1,300Y, 1,301S, 1,302G, 1,303Y, 1,332F, 1,362D
CDD
cd01647 (RT_LTR)

1,303Y

putative NTP binding site
1,298D, 1,299G, 1,300Y, 1,301S, 1,302G, 1,303Y, 1,332F, 1,362D
CDD
cd01647 (RT_LTR)

1,332F

putative NTP binding site
1,298D, 1,299G, 1,300Y, 1,301S, 1,302G, 1,303Y, 1,332F, 1,362D
CDD
cd01647 (RT_LTR)

1,362D

putative NTP binding site
1,298D, 1,299G, 1,300Y, 1,301S, 1,302G, 1,303Y, 1,332F, 1,362D
CDD
cd01647 (RT_LTR)
putative active si...

1,298D

putative active site
1,298D, 1,299G, 1,300Y, 1,301S, 1,302G, 1,303Y, 1,332F, 1,333G, 1,360F, 1,362D, 1,363D, 1,406L, 1,407G
CDD
cd01647 (RT_LTR)

1,299G

putative active site
1,298D, 1,299G, 1,300Y, 1,301S, 1,302G, 1,303Y, 1,332F, 1,333G, 1,360F, 1,362D, 1,363D, 1,406L, 1,407G
CDD
cd01647 (RT_LTR)

1,300Y

putative active site
1,298D, 1,299G, 1,300Y, 1,301S, 1,302G, 1,303Y, 1,332F, 1,333G, 1,360F, 1,362D, 1,363D, 1,406L, 1,407G
CDD
cd01647 (RT_LTR)

1,301S

putative active site
1,298D, 1,299G, 1,300Y, 1,301S, 1,302G, 1,303Y, 1,332F, 1,333G, 1,360F, 1,362D, 1,363D, 1,406L, 1,407G
CDD
cd01647 (RT_LTR)

1,302G

putative active site
1,298D, 1,299G, 1,300Y, 1,301S, 1,302G, 1,303Y, 1,332F, 1,333G, 1,360F, 1,362D, 1,363D, 1,406L, 1,407G
CDD
cd01647 (RT_LTR)

1,303Y

putative active site
1,298D, 1,299G, 1,300Y, 1,301S, 1,302G, 1,303Y, 1,332F, 1,333G, 1,360F, 1,362D, 1,363D, 1,406L, 1,407G
CDD
cd01647 (RT_LTR)

1,332F

putative active site
1,298D, 1,299G, 1,300Y, 1,301S, 1,302G, 1,303Y, 1,332F, 1,333G, 1,360F, 1,362D, 1,363D, 1,406L, 1,407G
CDD
cd01647 (RT_LTR)

1,333G

putative active site
1,298D, 1,299G, 1,300Y, 1,301S, 1,302G, 1,303Y, 1,332F, 1,333G, 1,360F, 1,362D, 1,363D, 1,406L, 1,407G
CDD
cd01647 (RT_LTR)

1,360F

putative active site
1,298D, 1,299G, 1,300Y, 1,301S, 1,302G, 1,303Y, 1,332F, 1,333G, 1,360F, 1,362D, 1,363D, 1,406L, 1,407G
CDD
cd01647 (RT_LTR)

1,362D

putative active site
1,298D, 1,299G, 1,300Y, 1,301S, 1,302G, 1,303Y, 1,332F, 1,333G, 1,360F, 1,362D, 1,363D, 1,406L, 1,407G
CDD
cd01647 (RT_LTR)

1,363D

putative active site
1,298D, 1,299G, 1,300Y, 1,301S, 1,302G, 1,303Y, 1,332F, 1,333G, 1,360F, 1,362D, 1,363D, 1,406L, 1,407G
CDD
cd01647 (RT_LTR)

1,406L

putative active site
1,298D, 1,299G, 1,300Y, 1,301S, 1,302G, 1,303Y, 1,332F, 1,333G, 1,360F, 1,362D, 1,363D, 1,406L, 1,407G
CDD
cd01647 (RT_LTR)

1,407G

putative active site
1,298D, 1,299G, 1,300Y, 1,301S, 1,302G, 1,303Y, 1,332F, 1,333G, 1,360F, 1,362D, 1,363D, 1,406L, 1,407G
CDD
cd01647 (RT_LTR)
putative nucleic a...

1,333G

putative nucleic acid binding site
1,333G
CDD
cd01647 (RT_LTR)
RNA/DNA hybrid bin...

1,508D

RNA/DNA hybrid binding site
1,508D, 1,509A, 1,510S, 1,511N, 1,546S, 1,547T, 1,548T, 1,551E, 1,576D, 1,609Y, 1,623R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,509A

RNA/DNA hybrid binding site
1,508D, 1,509A, 1,510S, 1,511N, 1,546S, 1,547T, 1,548T, 1,551E, 1,576D, 1,609Y, 1,623R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,510S

RNA/DNA hybrid binding site
1,508D, 1,509A, 1,510S, 1,511N, 1,546S, 1,547T, 1,548T, 1,551E, 1,576D, 1,609Y, 1,623R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,511N

RNA/DNA hybrid binding site
1,508D, 1,509A, 1,510S, 1,511N, 1,546S, 1,547T, 1,548T, 1,551E, 1,576D, 1,609Y, 1,623R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,546S

RNA/DNA hybrid binding site
1,508D, 1,509A, 1,510S, 1,511N, 1,546S, 1,547T, 1,548T, 1,551E, 1,576D, 1,609Y, 1,623R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,547T

RNA/DNA hybrid binding site
1,508D, 1,509A, 1,510S, 1,511N, 1,546S, 1,547T, 1,548T, 1,551E, 1,576D, 1,609Y, 1,623R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,548T

RNA/DNA hybrid binding site
1,508D, 1,509A, 1,510S, 1,511N, 1,546S, 1,547T, 1,548T, 1,551E, 1,576D, 1,609Y, 1,623R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,551E

RNA/DNA hybrid binding site
1,508D, 1,509A, 1,510S, 1,511N, 1,546S, 1,547T, 1,548T, 1,551E, 1,576D, 1,609Y, 1,623R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,576D

RNA/DNA hybrid binding site
1,508D, 1,509A, 1,510S, 1,511N, 1,546S, 1,547T, 1,548T, 1,551E, 1,576D, 1,609Y, 1,623R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,609Y

RNA/DNA hybrid binding site
1,508D, 1,509A, 1,510S, 1,511N, 1,546S, 1,547T, 1,548T, 1,551E, 1,576D, 1,609Y, 1,623R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,623R

RNA/DNA hybrid binding site
1,508D, 1,509A, 1,510S, 1,511N, 1,546S, 1,547T, 1,548T, 1,551E, 1,576D, 1,609Y, 1,623R
CDD
cd09274 (RNase_HI_RT_Ty3)

GO term prediction

Biological Process

GO:0015074 DNA integration

Molecular Function

GO:0003676 nucleic acid binding

Cellular Component