Mp7g16380.1

Protein

Length

572 amino acids

Protein family membership

Ribonuclease III (IPR011907)

Homologous superfamilies

Homologous superfamily
209 - 390
Ribonuclease III, endonuclease domain superfamily (IPR036389)

1 100 200 300 400 500 572

Domains and repeats

Domain
213 - 384
Ribonuclease III domain (IPR000999)
387 - 451
Double-stranded RNA-binding domain (IPR014720)
497 - 571
Double-stranded RNA-binding domain (IPR014720)

1 100 200 300 400 500 572

Detailed signature matches

IPR036389

Ribonuclease III, endonuclease domain superfamily
1. G3DSA:1.10.15...
  
  209 - 390
  
  GENE3D
  G3DSA:1.10.1520.10 (G3DSA:1.10.1520.10)
2. SSF69065 (RNase III...)
  
  212 - 311
  
  SUPERFAMILY
  SSF69065 (RNase III domain-like)
  
  341 - 381
  
  SUPERFAMILY
  SSF69065 (RNase III domain-like)
IPR011907

Ribonuclease III
1. MF_00104 (RNase_III)
  
  216 - 446
  
  HAMAP
  MF_00104 (RNase_III)
IPR000999

Ribonuclease III domain
1. cd00593 (RIBOc)
  
  229 - 384
  
  CDD
  cd00593 (RIBOc)
2. PF00636 (Ribonuclea...)
  
  248 - 361
  
  Pfam
  PF00636 (Ribonuclease_3)
3. PS00517 (RNASE_3_1)
  
  248 - 256
  
  PROSITE patterns
  PS00517 (RNASE_3_1)
4. SM00535 (riboneu5)
  
  228 - 384
  
  SMART
  SM00535 (riboneu5)
5. PS50142 (RNASE_3_2)
  
  213 - 361
  
  PROSITE profiles
  PS50142 (RNASE_3_2)
IPR014720

Double-stranded RNA-binding domain
1. PS50137 (DS_RBD)
  
  497 - 571
  
  PROSITE profiles
  PS50137 (DS_RBD)
  
  387 - 451
  
  PROSITE profiles
  PS50137 (DS_RBD)
2. SM00358 (DRBM_3)
  
  388 - 450
  
  SMART
  SM00358 (DRBM_3)
  
  498 - 570
  
  SMART
  SM00358 (DRBM_3)
3. PF00035 (dsrm)
  
  388 - 446
  
  Pfam
  PF00035 (dsrm)

no IPR

Unintegrated signatures

G3DSA:3.30.16...

503 - 571

GENE3D
G3DSA:3.30.160.20 (G3DSA:3.30.160.20)

391 - 456

GENE3D
G3DSA:3.30.160.20 (G3DSA:3.30.160.20)
PF14709 (DND1_DSRM)

499 - 570

Pfam
PF14709 (DND1_DSRM)
PS51257 (PROKAR_LIP...)

1 - 22

PROSITE profiles
PS51257 (PROKAR_LIPOPROTEIN)
PTHR14950 (DICER-RE...)

190 - 571

PANTHER
PTHR14950 (DICER-RELATED)
PTHR14950:SF44 (END...)

190 - 571

PANTHER
PTHR14950:SF44 (ENDORIBONUCLEASE DICER HOMOLOG 1)
SSF54768 (dsRNA-bin...)

495 - 571

SUPERFAMILY
SSF54768 (dsRNA-binding domain-like)

343 - 452

SUPERFAMILY
SSF54768 (dsRNA-binding domain-like)
cd19869 (DSRM_DCL_p...)

504 - 571

CDD
cd19869 (DSRM_DCL_plant)

Residue annotation

active site cd00593

248Q

active site
248Q, 251E, 255D, 347D, 350E
CDD
cd00593 (RIBOc)

251E

active site
248Q, 251E, 255D, 347D, 350E
CDD
cd00593 (RIBOc)

255D

active site
248Q, 251E, 255D, 347D, 350E
CDD
cd00593 (RIBOc)

347D

active site
248Q, 251E, 255D, 347D, 350E
CDD
cd00593 (RIBOc)

350E

active site
248Q, 251E, 255D, 347D, 350E
CDD
cd00593 (RIBOc)
dimerization inter...

248Q

dimerization interface
248Q, 249R, 252F, 253V, 256A, 259D, 260H, 263T, 264K, 266F, 267F, 268V, 278L, 357F, 368W
CDD
cd00593 (RIBOc)

249R

dimerization interface
248Q, 249R, 252F, 253V, 256A, 259D, 260H, 263T, 264K, 266F, 267F, 268V, 278L, 357F, 368W
CDD
cd00593 (RIBOc)

252F

dimerization interface
248Q, 249R, 252F, 253V, 256A, 259D, 260H, 263T, 264K, 266F, 267F, 268V, 278L, 357F, 368W
CDD
cd00593 (RIBOc)

253V

dimerization interface
248Q, 249R, 252F, 253V, 256A, 259D, 260H, 263T, 264K, 266F, 267F, 268V, 278L, 357F, 368W
CDD
cd00593 (RIBOc)

256A

dimerization interface
248Q, 249R, 252F, 253V, 256A, 259D, 260H, 263T, 264K, 266F, 267F, 268V, 278L, 357F, 368W
CDD
cd00593 (RIBOc)

259D

dimerization interface
248Q, 249R, 252F, 253V, 256A, 259D, 260H, 263T, 264K, 266F, 267F, 268V, 278L, 357F, 368W
CDD
cd00593 (RIBOc)

260H

dimerization interface
248Q, 249R, 252F, 253V, 256A, 259D, 260H, 263T, 264K, 266F, 267F, 268V, 278L, 357F, 368W
CDD
cd00593 (RIBOc)

263T

dimerization interface
248Q, 249R, 252F, 253V, 256A, 259D, 260H, 263T, 264K, 266F, 267F, 268V, 278L, 357F, 368W
CDD
cd00593 (RIBOc)

264K

dimerization interface
248Q, 249R, 252F, 253V, 256A, 259D, 260H, 263T, 264K, 266F, 267F, 268V, 278L, 357F, 368W
CDD
cd00593 (RIBOc)

266F

dimerization interface
248Q, 249R, 252F, 253V, 256A, 259D, 260H, 263T, 264K, 266F, 267F, 268V, 278L, 357F, 368W
CDD
cd00593 (RIBOc)

267F

dimerization interface
248Q, 249R, 252F, 253V, 256A, 259D, 260H, 263T, 264K, 266F, 267F, 268V, 278L, 357F, 368W
CDD
cd00593 (RIBOc)

268V

dimerization interface
248Q, 249R, 252F, 253V, 256A, 259D, 260H, 263T, 264K, 266F, 267F, 268V, 278L, 357F, 368W
CDD
cd00593 (RIBOc)

278L

dimerization interface
248Q, 249R, 252F, 253V, 256A, 259D, 260H, 263T, 264K, 266F, 267F, 268V, 278L, 357F, 368W
CDD
cd00593 (RIBOc)

357F

dimerization interface
248Q, 249R, 252F, 253V, 256A, 259D, 260H, 263T, 264K, 266F, 267F, 268V, 278L, 357F, 368W
CDD
cd00593 (RIBOc)

368W

dimerization interface
248Q, 249R, 252F, 253V, 256A, 259D, 260H, 263T, 264K, 266F, 267F, 268V, 278L, 357F, 368W
CDD
cd00593 (RIBOc)
metal binding site...

251E

metal binding site
251E, 347D, 350E
CDD
cd00593 (RIBOc)

347D

metal binding site
251E, 347D, 350E
CDD
cd00593 (RIBOc)

350E

metal binding site
251E, 347D, 350E
CDD
cd00593 (RIBOc)
putative RNA bindi...

504E

putative RNA binding site
504E, 507M, 508S, 513K, 514P, 524L, 525A, 526H, 527A, 528K, 530F, 552P, 553S, 554V, 555K, 558K, 559D
CDD
cd19869 (DSRM_DCL_plant)

507M

putative RNA binding site
504E, 507M, 508S, 513K, 514P, 524L, 525A, 526H, 527A, 528K, 530F, 552P, 553S, 554V, 555K, 558K, 559D
CDD
cd19869 (DSRM_DCL_plant)

508S

putative RNA binding site
504E, 507M, 508S, 513K, 514P, 524L, 525A, 526H, 527A, 528K, 530F, 552P, 553S, 554V, 555K, 558K, 559D
CDD
cd19869 (DSRM_DCL_plant)

513K

putative RNA binding site
504E, 507M, 508S, 513K, 514P, 524L, 525A, 526H, 527A, 528K, 530F, 552P, 553S, 554V, 555K, 558K, 559D
CDD
cd19869 (DSRM_DCL_plant)

514P

putative RNA binding site
504E, 507M, 508S, 513K, 514P, 524L, 525A, 526H, 527A, 528K, 530F, 552P, 553S, 554V, 555K, 558K, 559D
CDD
cd19869 (DSRM_DCL_plant)

524L

putative RNA binding site
504E, 507M, 508S, 513K, 514P, 524L, 525A, 526H, 527A, 528K, 530F, 552P, 553S, 554V, 555K, 558K, 559D
CDD
cd19869 (DSRM_DCL_plant)

525A

putative RNA binding site
504E, 507M, 508S, 513K, 514P, 524L, 525A, 526H, 527A, 528K, 530F, 552P, 553S, 554V, 555K, 558K, 559D
CDD
cd19869 (DSRM_DCL_plant)

526H

putative RNA binding site
504E, 507M, 508S, 513K, 514P, 524L, 525A, 526H, 527A, 528K, 530F, 552P, 553S, 554V, 555K, 558K, 559D
CDD
cd19869 (DSRM_DCL_plant)

527A

putative RNA binding site
504E, 507M, 508S, 513K, 514P, 524L, 525A, 526H, 527A, 528K, 530F, 552P, 553S, 554V, 555K, 558K, 559D
CDD
cd19869 (DSRM_DCL_plant)

528K

putative RNA binding site
504E, 507M, 508S, 513K, 514P, 524L, 525A, 526H, 527A, 528K, 530F, 552P, 553S, 554V, 555K, 558K, 559D
CDD
cd19869 (DSRM_DCL_plant)

530F

putative RNA binding site
504E, 507M, 508S, 513K, 514P, 524L, 525A, 526H, 527A, 528K, 530F, 552P, 553S, 554V, 555K, 558K, 559D
CDD
cd19869 (DSRM_DCL_plant)

552P

putative RNA binding site
504E, 507M, 508S, 513K, 514P, 524L, 525A, 526H, 527A, 528K, 530F, 552P, 553S, 554V, 555K, 558K, 559D
CDD
cd19869 (DSRM_DCL_plant)

553S

putative RNA binding site
504E, 507M, 508S, 513K, 514P, 524L, 525A, 526H, 527A, 528K, 530F, 552P, 553S, 554V, 555K, 558K, 559D
CDD
cd19869 (DSRM_DCL_plant)

554V

putative RNA binding site
504E, 507M, 508S, 513K, 514P, 524L, 525A, 526H, 527A, 528K, 530F, 552P, 553S, 554V, 555K, 558K, 559D
CDD
cd19869 (DSRM_DCL_plant)

555K

putative RNA binding site
504E, 507M, 508S, 513K, 514P, 524L, 525A, 526H, 527A, 528K, 530F, 552P, 553S, 554V, 555K, 558K, 559D
CDD
cd19869 (DSRM_DCL_plant)

558K

putative RNA binding site
504E, 507M, 508S, 513K, 514P, 524L, 525A, 526H, 527A, 528K, 530F, 552P, 553S, 554V, 555K, 558K, 559D
CDD
cd19869 (DSRM_DCL_plant)

559D

putative RNA binding site
504E, 507M, 508S, 513K, 514P, 524L, 525A, 526H, 527A, 528K, 530F, 552P, 553S, 554V, 555K, 558K, 559D
CDD
cd19869 (DSRM_DCL_plant)

GO term prediction

Biological Process

GO:0006396 RNA processing
GO:0016075 rRNA catabolic process

Molecular Function

GO:0003723 RNA binding
GO:0004525 ribonuclease III activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features