Mp7g16380.2

Protein

Length

512 amino acids

Protein family membership

Ribonuclease III (IPR011907)

Homologous superfamilies

Homologous superfamily
149 - 330
Ribonuclease III, endonuclease domain superfamily (IPR036389)

1 50 100 150 200 250 300 350 400 450 512

Domains and repeats

Domain
153 - 324
Ribonuclease III domain (IPR000999)
327 - 391
Double-stranded RNA-binding domain (IPR014720)
437 - 511
Double-stranded RNA-binding domain (IPR014720)

1 50 100 150 200 250 300 350 400 450 512

Detailed signature matches

IPR036389

Ribonuclease III, endonuclease domain superfamily
1. G3DSA:1.10.15...
  
  149 - 330
  
  GENE3D
  G3DSA:1.10.1520.10 (G3DSA:1.10.1520.10)
2. SSF69065 (RNase III...)
  
  152 - 251
  
  SUPERFAMILY
  SSF69065 (RNase III domain-like)
  
  281 - 321
  
  SUPERFAMILY
  SSF69065 (RNase III domain-like)
IPR011907

Ribonuclease III
1. MF_00104 (RNase_III)
  
  156 - 386
  
  HAMAP
  MF_00104 (RNase_III)
IPR000999

Ribonuclease III domain
1. PS00517 (RNASE_3_1)
  
  188 - 196
  
  PROSITE patterns
  PS00517 (RNASE_3_1)
2. PF00636 (Ribonuclea...)
  
  188 - 301
  
  Pfam
  PF00636 (Ribonuclease_3)
3. cd00593 (RIBOc)
  
  169 - 324
  
  CDD
  cd00593 (RIBOc)
4. SM00535 (riboneu5)
  
  168 - 324
  
  SMART
  SM00535 (riboneu5)
5. PS50142 (RNASE_3_2)
  
  153 - 301
  
  PROSITE profiles
  PS50142 (RNASE_3_2)
IPR014720

Double-stranded RNA-binding domain
1. PS50137 (DS_RBD)
  
  437 - 511
  
  PROSITE profiles
  PS50137 (DS_RBD)
  
  327 - 391
  
  PROSITE profiles
  PS50137 (DS_RBD)
2. SM00358 (DRBM_3)
  
  328 - 390
  
  SMART
  SM00358 (DRBM_3)
  
  438 - 510
  
  SMART
  SM00358 (DRBM_3)
3. PF00035 (dsrm)
  
  328 - 386
  
  Pfam
  PF00035 (dsrm)

no IPR

Unintegrated signatures

G3DSA:3.30.16...

331 - 396

GENE3D
G3DSA:3.30.160.20 (G3DSA:3.30.160.20)

443 - 511

GENE3D
G3DSA:3.30.160.20 (G3DSA:3.30.160.20)
PF14709 (DND1_DSRM)

439 - 510

Pfam
PF14709 (DND1_DSRM)
PTHR14950 (DICER-RE...)

130 - 511

PANTHER
PTHR14950 (DICER-RELATED)
PTHR14950:SF44 (END...)

130 - 511

PANTHER
PTHR14950:SF44 (ENDORIBONUCLEASE DICER HOMOLOG 1)
SSF54768 (dsRNA-bin...)

435 - 511

SUPERFAMILY
SSF54768 (dsRNA-binding domain-like)

283 - 392

SUPERFAMILY
SSF54768 (dsRNA-binding domain-like)
cd19869 (DSRM_DCL_p...)

444 - 511

CDD
cd19869 (DSRM_DCL_plant)

Residue annotation

active site cd00593

188Q

active site
188Q, 191E, 195D, 287D, 290E
CDD
cd00593 (RIBOc)

191E

active site
188Q, 191E, 195D, 287D, 290E
CDD
cd00593 (RIBOc)

195D

active site
188Q, 191E, 195D, 287D, 290E
CDD
cd00593 (RIBOc)

287D

active site
188Q, 191E, 195D, 287D, 290E
CDD
cd00593 (RIBOc)

290E

active site
188Q, 191E, 195D, 287D, 290E
CDD
cd00593 (RIBOc)
dimerization inter...

188Q

dimerization interface
188Q, 189R, 192F, 193V, 196A, 199D, 200H, 203T, 204K, 206F, 207F, 208V, 218L, 297F, 308W
CDD
cd00593 (RIBOc)

189R

dimerization interface
188Q, 189R, 192F, 193V, 196A, 199D, 200H, 203T, 204K, 206F, 207F, 208V, 218L, 297F, 308W
CDD
cd00593 (RIBOc)

192F

dimerization interface
188Q, 189R, 192F, 193V, 196A, 199D, 200H, 203T, 204K, 206F, 207F, 208V, 218L, 297F, 308W
CDD
cd00593 (RIBOc)

193V

dimerization interface
188Q, 189R, 192F, 193V, 196A, 199D, 200H, 203T, 204K, 206F, 207F, 208V, 218L, 297F, 308W
CDD
cd00593 (RIBOc)

196A

dimerization interface
188Q, 189R, 192F, 193V, 196A, 199D, 200H, 203T, 204K, 206F, 207F, 208V, 218L, 297F, 308W
CDD
cd00593 (RIBOc)

199D

dimerization interface
188Q, 189R, 192F, 193V, 196A, 199D, 200H, 203T, 204K, 206F, 207F, 208V, 218L, 297F, 308W
CDD
cd00593 (RIBOc)

200H

dimerization interface
188Q, 189R, 192F, 193V, 196A, 199D, 200H, 203T, 204K, 206F, 207F, 208V, 218L, 297F, 308W
CDD
cd00593 (RIBOc)

203T

dimerization interface
188Q, 189R, 192F, 193V, 196A, 199D, 200H, 203T, 204K, 206F, 207F, 208V, 218L, 297F, 308W
CDD
cd00593 (RIBOc)

204K

dimerization interface
188Q, 189R, 192F, 193V, 196A, 199D, 200H, 203T, 204K, 206F, 207F, 208V, 218L, 297F, 308W
CDD
cd00593 (RIBOc)

206F

dimerization interface
188Q, 189R, 192F, 193V, 196A, 199D, 200H, 203T, 204K, 206F, 207F, 208V, 218L, 297F, 308W
CDD
cd00593 (RIBOc)

207F

dimerization interface
188Q, 189R, 192F, 193V, 196A, 199D, 200H, 203T, 204K, 206F, 207F, 208V, 218L, 297F, 308W
CDD
cd00593 (RIBOc)

208V

dimerization interface
188Q, 189R, 192F, 193V, 196A, 199D, 200H, 203T, 204K, 206F, 207F, 208V, 218L, 297F, 308W
CDD
cd00593 (RIBOc)

218L

dimerization interface
188Q, 189R, 192F, 193V, 196A, 199D, 200H, 203T, 204K, 206F, 207F, 208V, 218L, 297F, 308W
CDD
cd00593 (RIBOc)

297F

dimerization interface
188Q, 189R, 192F, 193V, 196A, 199D, 200H, 203T, 204K, 206F, 207F, 208V, 218L, 297F, 308W
CDD
cd00593 (RIBOc)

308W

dimerization interface
188Q, 189R, 192F, 193V, 196A, 199D, 200H, 203T, 204K, 206F, 207F, 208V, 218L, 297F, 308W
CDD
cd00593 (RIBOc)
metal binding site...

191E

metal binding site
191E, 287D, 290E
CDD
cd00593 (RIBOc)

287D

metal binding site
191E, 287D, 290E
CDD
cd00593 (RIBOc)

290E

metal binding site
191E, 287D, 290E
CDD
cd00593 (RIBOc)
putative RNA bindi...

444E

putative RNA binding site
444E, 447M, 448S, 453K, 454P, 464L, 465A, 466H, 467A, 468K, 470F, 492P, 493S, 494V, 495K, 498K, 499D
CDD
cd19869 (DSRM_DCL_plant)

447M

putative RNA binding site
444E, 447M, 448S, 453K, 454P, 464L, 465A, 466H, 467A, 468K, 470F, 492P, 493S, 494V, 495K, 498K, 499D
CDD
cd19869 (DSRM_DCL_plant)

448S

putative RNA binding site
444E, 447M, 448S, 453K, 454P, 464L, 465A, 466H, 467A, 468K, 470F, 492P, 493S, 494V, 495K, 498K, 499D
CDD
cd19869 (DSRM_DCL_plant)

453K

putative RNA binding site
444E, 447M, 448S, 453K, 454P, 464L, 465A, 466H, 467A, 468K, 470F, 492P, 493S, 494V, 495K, 498K, 499D
CDD
cd19869 (DSRM_DCL_plant)

454P

putative RNA binding site
444E, 447M, 448S, 453K, 454P, 464L, 465A, 466H, 467A, 468K, 470F, 492P, 493S, 494V, 495K, 498K, 499D
CDD
cd19869 (DSRM_DCL_plant)

464L

putative RNA binding site
444E, 447M, 448S, 453K, 454P, 464L, 465A, 466H, 467A, 468K, 470F, 492P, 493S, 494V, 495K, 498K, 499D
CDD
cd19869 (DSRM_DCL_plant)

465A

putative RNA binding site
444E, 447M, 448S, 453K, 454P, 464L, 465A, 466H, 467A, 468K, 470F, 492P, 493S, 494V, 495K, 498K, 499D
CDD
cd19869 (DSRM_DCL_plant)

466H

putative RNA binding site
444E, 447M, 448S, 453K, 454P, 464L, 465A, 466H, 467A, 468K, 470F, 492P, 493S, 494V, 495K, 498K, 499D
CDD
cd19869 (DSRM_DCL_plant)

467A

putative RNA binding site
444E, 447M, 448S, 453K, 454P, 464L, 465A, 466H, 467A, 468K, 470F, 492P, 493S, 494V, 495K, 498K, 499D
CDD
cd19869 (DSRM_DCL_plant)

468K

putative RNA binding site
444E, 447M, 448S, 453K, 454P, 464L, 465A, 466H, 467A, 468K, 470F, 492P, 493S, 494V, 495K, 498K, 499D
CDD
cd19869 (DSRM_DCL_plant)

470F

putative RNA binding site
444E, 447M, 448S, 453K, 454P, 464L, 465A, 466H, 467A, 468K, 470F, 492P, 493S, 494V, 495K, 498K, 499D
CDD
cd19869 (DSRM_DCL_plant)

492P

putative RNA binding site
444E, 447M, 448S, 453K, 454P, 464L, 465A, 466H, 467A, 468K, 470F, 492P, 493S, 494V, 495K, 498K, 499D
CDD
cd19869 (DSRM_DCL_plant)

493S

putative RNA binding site
444E, 447M, 448S, 453K, 454P, 464L, 465A, 466H, 467A, 468K, 470F, 492P, 493S, 494V, 495K, 498K, 499D
CDD
cd19869 (DSRM_DCL_plant)

494V

putative RNA binding site
444E, 447M, 448S, 453K, 454P, 464L, 465A, 466H, 467A, 468K, 470F, 492P, 493S, 494V, 495K, 498K, 499D
CDD
cd19869 (DSRM_DCL_plant)

495K

putative RNA binding site
444E, 447M, 448S, 453K, 454P, 464L, 465A, 466H, 467A, 468K, 470F, 492P, 493S, 494V, 495K, 498K, 499D
CDD
cd19869 (DSRM_DCL_plant)

498K

putative RNA binding site
444E, 447M, 448S, 453K, 454P, 464L, 465A, 466H, 467A, 468K, 470F, 492P, 493S, 494V, 495K, 498K, 499D
CDD
cd19869 (DSRM_DCL_plant)

499D

putative RNA binding site
444E, 447M, 448S, 453K, 454P, 464L, 465A, 466H, 467A, 468K, 470F, 492P, 493S, 494V, 495K, 498K, 499D
CDD
cd19869 (DSRM_DCL_plant)

GO term prediction

Biological Process

GO:0006396 RNA processing
GO:0016075 rRNA catabolic process

Molecular Function

GO:0003723 RNA binding
GO:0004525 ribonuclease III activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features