Mp8g16970.1

Protein

Length

630 amino acids

Protein family membership

D-3-phosphoglycerate dehydrogenase (IPR006236)

Homologous superfamilies

Homologous superfamily
188 - 370
NAD(P)-binding domain superfamily (IPR036291)
406 - 556
Allosteric substrate binding domain superfamily (IPR029009)

1 100 200 300 400 500 630

Domains and repeats

Domain
92 - 401
D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain (IPR006139)
Domain
194 - 369
D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain (IPR006140)
Domain
219 - 373
S-adenosyl-L-homocysteine hydrolase, NAD binding domain (IPR015878)
558 - 630
ACT domain (IPR002912)

1 100 200 300 400 500 630

Detailed signature matches

IPR036291

NAD(P)-binding domain superfamily
1. SSF51735 (NAD(P)-bi...)
  
  188 - 370
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR029009

Allosteric substrate binding domain superfamily
1. SSF143548 (Serine m...)
  
  407 - 552
  
  SUPERFAMILY
  SSF143548 (Serine metabolism enzymes domain)
2. G3DSA:3.30.13...
  
  406 - 556
  
  GENE3D
  G3DSA:3.30.1330.90 (G3DSA:3.30.1330.90)
IPR006236

D-3-phosphoglycerate dehydrogenase
1. TIGR01327
  
  92 - 628
  
  TIGRFAMs
  TIGR01327 (TIGR01327)
IPR006139

D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
1. PF00389 (2-Hacid_dh)
  
  92 - 193
  
  Pfam
  PF00389 (2-Hacid_dh)
  
  370 - 401
  
  Pfam
  PF00389 (2-Hacid_dh)
IPR006140

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
1. PF02826 (2-Hacid_dh_C)
  
  194 - 369
  
  Pfam
  PF02826 (2-Hacid_dh_C)
IPR015878

S-adenosyl-L-homocysteine hydrolase, NAD binding domain
1. SM00997 (AdoHcyase_...)
  
  219 - 373
  
  SMART
  SM00997 (AdoHcyase_NAD_2)
IPR002912

ACT domain
1. PF01842 (ACT)
  
  558 - 618
  
  Pfam
  PF01842 (ACT)
2. PS51671 (ACT)
  
  558 - 630
  
  PROSITE profiles
  PS51671 (ACT)
IPR029752

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1
1. PS00065 (D_2_HYDROX...)
  
  231 - 258
  
  PROSITE patterns
  PS00065 (D_2_HYDROXYACID_DH_1)
IPR029753

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site
1. PS00671 (D_2_HYDROX...)
  
  308 - 324
  
  PROSITE patterns
  PS00671 (D_2_HYDROXYACID_DH_3)

no IPR

Unintegrated signatures

G3DSA:3.30.70...

557 - 630

GENE3D
G3DSA:3.30.70.260 (G3DSA:3.30.70.260)
G3DSA:3.40.50...

368 - 393

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)

93 - 184

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)

185 - 367

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
PTHR42938 (FORMATE ...)

77 - 625

PANTHER
PTHR42938 (FORMATE DEHYDROGENASE 1)
PTHR42938:SF22 (D-3...)

77 - 625

PANTHER
PTHR42938:SF22 (D-3-PHOSPHOGLYCERATE DEHYDROGENASE 2, CHLOROPLASTIC)
SSF52283 (Formate/g...)

89 - 218

SUPERFAMILY
SSF52283 (Formate/glycerate dehydrogenase catalytic domain-like)
SSF55021 (ACT-like)

556 - 627

SUPERFAMILY
SSF55021 (ACT-like)
cd04902 (ACT_3PGDH-xct)

559 - 630

CDD
cd04902 (ACT_3PGDH-xct)
cd12173 (PGDH_4)

92 - 394

CDD
cd12173 (PGDH_4)

Residue annotation

ligand binding sit...

136R

ligand binding site
136R, 137S, 158R, 160G, 161V, 185N, 319R, 367H, 370A, 376Q
CDD
cd12173 (PGDH_4)

137S

ligand binding site
136R, 137S, 158R, 160G, 161V, 185N, 319R, 367H, 370A, 376Q
CDD
cd12173 (PGDH_4)

158R

ligand binding site
136R, 137S, 158R, 160G, 161V, 185N, 319R, 367H, 370A, 376Q
CDD
cd12173 (PGDH_4)

160G

ligand binding site
136R, 137S, 158R, 160G, 161V, 185N, 319R, 367H, 370A, 376Q
CDD
cd12173 (PGDH_4)

161V

ligand binding site
136R, 137S, 158R, 160G, 161V, 185N, 319R, 367H, 370A, 376Q
CDD
cd12173 (PGDH_4)

185N

ligand binding site
136R, 137S, 158R, 160G, 161V, 185N, 319R, 367H, 370A, 376Q
CDD
cd12173 (PGDH_4)

319R

ligand binding site
136R, 137S, 158R, 160G, 161V, 185N, 319R, 367H, 370A, 376Q
CDD
cd12173 (PGDH_4)

367H

ligand binding site
136R, 137S, 158R, 160G, 161V, 185N, 319R, 367H, 370A, 376Q
CDD
cd12173 (PGDH_4)

370A

ligand binding site
136R, 137S, 158R, 160G, 161V, 185N, 319R, 367H, 370A, 376Q
CDD
cd12173 (PGDH_4)

376Q

ligand binding site
136R, 137S, 158R, 160G, 161V, 185N, 319R, 367H, 370A, 376Q
CDD
cd12173 (PGDH_4)
NAD binding site c...

161V

NAD binding site
161V, 185N, 189A, 235G, 237G, 238K, 239V, 257H, 258D, 259P, 260Y, 289H, 290M, 291P, 296T, 317V, 318A, 319R, 343D, 344V, 367H, 369G, 370A
CDD
cd12173 (PGDH_4)

185N

NAD binding site
161V, 185N, 189A, 235G, 237G, 238K, 239V, 257H, 258D, 259P, 260Y, 289H, 290M, 291P, 296T, 317V, 318A, 319R, 343D, 344V, 367H, 369G, 370A
CDD
cd12173 (PGDH_4)

189A

NAD binding site
161V, 185N, 189A, 235G, 237G, 238K, 239V, 257H, 258D, 259P, 260Y, 289H, 290M, 291P, 296T, 317V, 318A, 319R, 343D, 344V, 367H, 369G, 370A
CDD
cd12173 (PGDH_4)

235G

NAD binding site
161V, 185N, 189A, 235G, 237G, 238K, 239V, 257H, 258D, 259P, 260Y, 289H, 290M, 291P, 296T, 317V, 318A, 319R, 343D, 344V, 367H, 369G, 370A
CDD
cd12173 (PGDH_4)

237G

NAD binding site
161V, 185N, 189A, 235G, 237G, 238K, 239V, 257H, 258D, 259P, 260Y, 289H, 290M, 291P, 296T, 317V, 318A, 319R, 343D, 344V, 367H, 369G, 370A
CDD
cd12173 (PGDH_4)

238K

NAD binding site
161V, 185N, 189A, 235G, 237G, 238K, 239V, 257H, 258D, 259P, 260Y, 289H, 290M, 291P, 296T, 317V, 318A, 319R, 343D, 344V, 367H, 369G, 370A
CDD
cd12173 (PGDH_4)

239V

NAD binding site
161V, 185N, 189A, 235G, 237G, 238K, 239V, 257H, 258D, 259P, 260Y, 289H, 290M, 291P, 296T, 317V, 318A, 319R, 343D, 344V, 367H, 369G, 370A
CDD
cd12173 (PGDH_4)

257H

NAD binding site
161V, 185N, 189A, 235G, 237G, 238K, 239V, 257H, 258D, 259P, 260Y, 289H, 290M, 291P, 296T, 317V, 318A, 319R, 343D, 344V, 367H, 369G, 370A
CDD
cd12173 (PGDH_4)

258D

NAD binding site
161V, 185N, 189A, 235G, 237G, 238K, 239V, 257H, 258D, 259P, 260Y, 289H, 290M, 291P, 296T, 317V, 318A, 319R, 343D, 344V, 367H, 369G, 370A
CDD
cd12173 (PGDH_4)

259P

NAD binding site
161V, 185N, 189A, 235G, 237G, 238K, 239V, 257H, 258D, 259P, 260Y, 289H, 290M, 291P, 296T, 317V, 318A, 319R, 343D, 344V, 367H, 369G, 370A
CDD
cd12173 (PGDH_4)

260Y

NAD binding site
161V, 185N, 189A, 235G, 237G, 238K, 239V, 257H, 258D, 259P, 260Y, 289H, 290M, 291P, 296T, 317V, 318A, 319R, 343D, 344V, 367H, 369G, 370A
CDD
cd12173 (PGDH_4)

289H

NAD binding site
161V, 185N, 189A, 235G, 237G, 238K, 239V, 257H, 258D, 259P, 260Y, 289H, 290M, 291P, 296T, 317V, 318A, 319R, 343D, 344V, 367H, 369G, 370A
CDD
cd12173 (PGDH_4)

290M

NAD binding site
161V, 185N, 189A, 235G, 237G, 238K, 239V, 257H, 258D, 259P, 260Y, 289H, 290M, 291P, 296T, 317V, 318A, 319R, 343D, 344V, 367H, 369G, 370A
CDD
cd12173 (PGDH_4)

291P

NAD binding site
161V, 185N, 189A, 235G, 237G, 238K, 239V, 257H, 258D, 259P, 260Y, 289H, 290M, 291P, 296T, 317V, 318A, 319R, 343D, 344V, 367H, 369G, 370A
CDD
cd12173 (PGDH_4)

296T

NAD binding site
161V, 185N, 189A, 235G, 237G, 238K, 239V, 257H, 258D, 259P, 260Y, 289H, 290M, 291P, 296T, 317V, 318A, 319R, 343D, 344V, 367H, 369G, 370A
CDD
cd12173 (PGDH_4)

317V

NAD binding site
161V, 185N, 189A, 235G, 237G, 238K, 239V, 257H, 258D, 259P, 260Y, 289H, 290M, 291P, 296T, 317V, 318A, 319R, 343D, 344V, 367H, 369G, 370A
CDD
cd12173 (PGDH_4)

318A

NAD binding site
161V, 185N, 189A, 235G, 237G, 238K, 239V, 257H, 258D, 259P, 260Y, 289H, 290M, 291P, 296T, 317V, 318A, 319R, 343D, 344V, 367H, 369G, 370A
CDD
cd12173 (PGDH_4)

319R

NAD binding site
161V, 185N, 189A, 235G, 237G, 238K, 239V, 257H, 258D, 259P, 260Y, 289H, 290M, 291P, 296T, 317V, 318A, 319R, 343D, 344V, 367H, 369G, 370A
CDD
cd12173 (PGDH_4)

343D

NAD binding site
161V, 185N, 189A, 235G, 237G, 238K, 239V, 257H, 258D, 259P, 260Y, 289H, 290M, 291P, 296T, 317V, 318A, 319R, 343D, 344V, 367H, 369G, 370A
CDD
cd12173 (PGDH_4)

344V

NAD binding site
161V, 185N, 189A, 235G, 237G, 238K, 239V, 257H, 258D, 259P, 260Y, 289H, 290M, 291P, 296T, 317V, 318A, 319R, 343D, 344V, 367H, 369G, 370A
CDD
cd12173 (PGDH_4)

367H

NAD binding site
161V, 185N, 189A, 235G, 237G, 238K, 239V, 257H, 258D, 259P, 260Y, 289H, 290M, 291P, 296T, 317V, 318A, 319R, 343D, 344V, 367H, 369G, 370A
CDD
cd12173 (PGDH_4)

369G

NAD binding site
161V, 185N, 189A, 235G, 237G, 238K, 239V, 257H, 258D, 259P, 260Y, 289H, 290M, 291P, 296T, 317V, 318A, 319R, 343D, 344V, 367H, 369G, 370A
CDD
cd12173 (PGDH_4)

370A

NAD binding site
161V, 185N, 189A, 235G, 237G, 238K, 239V, 257H, 258D, 259P, 260Y, 289H, 290M, 291P, 296T, 317V, 318A, 319R, 343D, 344V, 367H, 369G, 370A
CDD
cd12173 (PGDH_4)
dimerization inter...

187I

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

188A

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

191E

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

192H

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

194I

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

195A

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

198T

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

199A

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

202R

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

204V

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

205A

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

207A

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

208S

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

211M

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

212K

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

214G

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

215E

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

216W

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

218R

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

221Y

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

222V

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

223G

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

224V

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

225S

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

226L

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

227V

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

229K

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

246R

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

249G

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

250L

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

345F

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

348E

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

349P

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

350P

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

356L

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

357I

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

358Q

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

359H

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

360E

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

362V

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

363V

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

364V

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

365T

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

366P

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

367H

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

368L

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

369G

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

371S

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

372T

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

373M

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

374E

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)

378G

dimerization interface
187I, 188A, 191E, 192H, 194I, 195A, 198T, 199A, 202R, 204V, 205A, 207A, 208S, 211M, 212K, 214G, 215E, 216W, 218R, 221Y, 222V, 223G, 224V, 225S, 226L, 227V, 229K, 246R, 249G, 250L, 345F, 348E, 349P, 350P, 356L, 357I, 358Q, 359H, 360E, 362V, 363V, 364V, 365T, 366P, 367H, 368L, 369G, 371S, 372T, 373M, 374E, 378G
CDD
cd12173 (PGDH_4)
putative L-serine ...

563Q

putative L-serine binding site
563Q, 565D, 583N
CDD
cd04902 (ACT_3PGDH-xct)

565D

putative L-serine binding site
563Q, 565D, 583N
CDD
cd04902 (ACT_3PGDH-xct)

583N

putative L-serine binding site
563Q, 565D, 583N
CDD
cd04902 (ACT_3PGDH-xct)

GO term prediction

Biological Process

GO:0006564 L-serine biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004617 phosphoglycerate dehydrogenase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

Cellular Component

None predicted.

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Entry type

Status

Per-residue features