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Phytophthora palmivora establishes tissue-specific intracellular infection structures in the earliest divergent land plant lineage.

Carella, P., et al. · 2018 · Proceedings of the National Academy of Sciences USA: doi/10.1073/pnas.1717900115   research

doi:10.1073/pnas.1717900115   PMID:29615512   PMC5910834

Linked genes (8)  4 core 4 peripheral

Gene ID Name Evidence / Role Function (this paper)
Mp5g16920 MpDIR33 experimental subject Dirigent-like defense marker; expression was significantly higher in infected plants than controls by qRT-PCR, consistent with prior reports of up-regulation in pathogen-treated moss.
MpVg00760
MpRAB11A paper
MpRAB11AY nomenclature
experimental subject Endosomal Rab GTPase; overexpressed mCitrine-MpRab11A accumulated at pathogen interfaces and intracellular hyphae during infection, relocalizing from endosomes, indicating trafficking recruitment to infection structures.
Mp8g13820 MpRAB7 experimental subject Endosomal Rab GTPase; mCitrine-MpRab7 transgenic plants showed strong labeling of intracellular infection structures and hyphae in living Marchantia cells at 3 dpi, indicating recruitment of trafficking machinery to the pathogen interface.
Mp2g19600 MpSYP13B experimental subject Membrane syntaxin significantly up-regulated from 2 to 4 dpi during Phytophthora palmivora infection. mCitrine-MpSYP13B strongly labeled intracellular infection structures, showing focal accumulation proximal to hyphal buds and complete labeling around intracellular hyphae, suggesting it evolved to mark intracellular accommodation structures in liverworts.
Mp5g21510 MpPR9l experimental comparator Peroxidase used as a host defense marker; transcript levels were significantly higher in P. palmivora-colonized TAK1 plants than mock controls by 3 dpi, and MpPRX:GUS reporter lines showed strong GUS induction in the photosynthetic layer during infection.
Mp7g13190 MpSYP13A experimental comparator Paralogous syntaxin used as contrast to MpSYP13B; its expression was not affected during colonization and its localization was unchanged by intracellular infection structures.
MpACT missing sequence tool Actin gene used as an internal reference for qRT-PCR normalization and as a M. polymorpha biomass marker for relative pathogen biomass quantification.
Mp3g23400 MpEF1 sequence tool Elongation factor 1-alpha used as an internal qRT-PCR reference and host biomass marker against which P. palmivora PpEF1a biomass was quantified.