← Literature list

Conserved redox- dependent DNA binding of ROXY glutaredoxins with TGA transcription factors.

Gutsche, N., et al. · 2017 · Plant Direct   research

doi:10.1002/pld3.30   PMID:31245678   PMC6508501

Linked genes (4)  3 core 1 peripheral

Gene ID Name Evidence / Role Function (this paper)
Mp5g10600 MpROXY1 experimental subject Functionally studied ROXY glutaredoxin: complemented Arabidopsis roxy1-2 flower defect, interacted with MpTGA/PAN by Y2H, BiFC and FRET-FLIM (C-terminal deletion MpROXY1Δ14 abolished binding), and gave redox-dependent supershift on the as-1-like motif by EMSA. Overexpression in M. polymorpha caused severe growth defects requiring active-site cysteines, and GFP fusions colocalized with active RNAPII; shown conserved with Arabidopsis ROXY1.
Mp6g13210 MpROXY2 experimental subject Functionally studied ROXY glutaredoxin: partially complemented Arabidopsis roxy1-2 petals and interacted (more weakly than MpROXY1) with MpTGA/PAN by Y2H, BiFC and FRET-FLIM, giving an incomplete redox-dependent supershift on the as-1-like motif by EMSA. Overexpression caused cysteine-dependent growth defects and in situ mRNA overlapped MpTGA in thallus tips and gemmae.
Mp2g13330 MpTGA experimental subject Functionally studied TGA transcription factor: bound the as-1-like motif specifically by EMSA with redox sensitivity mediated jointly by cysteines C143/C231 (oxidation reduced binding, reversed by DTT), and formed redox-dependent supershifted complexes with MpROXY1/2. Interacted with ROXYs by Y2H/BiFC/FRET-FLIM and expressed in meristematic zones and gemmae overlapping MpROXY1/2.
Mp3g23400 MpEF1 sequence tool Its promoter (MpEF1alpha) was used to drive ectopic MpROXY1/MpROXY2 CDS expression in M. polymorpha overexpression lines.