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Induction of Multichotomous Branching by CLAVATA Peptide in Marchantia polymorpha.

Hirakawa, Y., et al. · 2020 · Current Biology   research

doi:10.1016/j.cub.2020.07.016   PMID:32822612

Linked genes (8)  3 core 5 peripheral

Gene ID Name Evidence / Role Function (this paper)
Mp5g18050 MpCLE2 experimental subject Gene ID for MpCLE2, the CLV3 ortholog whose peptide promotes stem cell accumulation and multichotomous branching when applied then removed.
Mp1g27720 MpCLV1 experimental subject Gene ID for MpCLV1 (MpCLAVATA1), the CLV1-ortholog receptor; knockouts are insensitive to MpCLE2 peptide, identifying it as the primary MpCLE2 receptor.
Mp1g11660 MpWOX experimental subject Gene ID for MpWOX, the sole WUS-related gene in M. polymorpha; loss-of-function alleles tested to show MpCLE2 signaling is WOX-independent.
MpCLV3 missing sequence comparator Used as a synonym/cross-species label for MpCLE2 (the CLV3 ortholog), e.g. "MpCLE2/MpCLV3 Signaling"; Arabidopsis CLV3 is the orthologous flowering-plant peptide.
Mp1g09960 MpTDR citation comparator Receptor for MpCLE1 (distinct from MpCLV1) mediating cell-proliferation control; cited from prior work to contrast the two independent CLE signaling pathways.
Mp3g23400 MpEF1 experimental tool Promoter (proMpEF1a) used to drive ectopic MpCLE2 overexpression in transgenic lines.
Mp8g08780 MpYUC2 experimental tool Used as a marker (proMpYUC2:GUS) for the apical notch/undifferentiated cells and as a promoter driving MpCLE2 or MpCLV1; marks the stem-cell region whose expansion reports MpCLE2 activity.
Mp6g07050 MpCLE1 citation background Gene ID for MpCLE1, the other CLE subclass; cited from prior work as a negative regulator of cell proliferation acting via MpTDR, not studied functionally here.