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Origin and early evolution of the plant terpene synthase family.

Jia, Q., et al. · 2022 · PNAS   research

doi:10.1073/pnas.2100361119   PMID:35394876   PMC9169658

Linked genes (3)  3 core 0 peripheral

Gene ID	Name	Evidence / Role	Function (this paper)
—	MpCPS missing	experimental subject	Liverwort TPS biochemically characterized as a monofunctional class II copalyl diphosphate synthase that stereoselectively produces ent-CPP, having lost class I (KS) activity. Cited as evidence of independent CPS subfunctionalization in liverworts during early plant terpene synthase evolution.
—	MpDTPS3 missing	experimental subject	Liverwort TPS shown to be a monofunctional CPS producing ent-CPP, exemplifying parallel loss of class I activity in the liverwort lineage. Functionally placed alongside MpCPS as an independently evolved monofunctional copalyl diphosphate synthase.
—	MpDTPS5 missing	experimental subject	Liverwort TPS characterized as a monofunctional class II diterpene cyclase that produces rearranged KPP (kaurene-type precursor) rather than CPP, illustrating product diversification after loss of class I activity. Demonstrates specialized class II catalysis in liverwort terpene metabolism.