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An ancient role for CYP73 monooxygenases in phenylpropanoid biosynthesis and embryophyte development.

Knosp, S., et al. · 2024 · The EMBO Journal   research

doi:10.1038/s44318-024-00181-7   PMID:39090438   PMC11405693

Linked genes (5)  1 core 4 peripheral

Gene ID	Name	Evidence / Role	Function (this paper)
Mp6g00020	MpC4H paper MpC4H1 nomenclature	experimental subject	Primary, most highly expressed CYP73A paralog in M. polymorpha; encoded protein shows C4H activity in vitro. CRISPR mutants display dramatically reduced thallus area and fewer gemmae cups, with ~50% drop in two essential phenylpropanoid pathway intermediates.
—	MpCYP73A2 missing	sequence comparator	One of two additional, lowly expressed MpCYP73A paralogs contributing to genetic redundancy in M. polymorpha.
—	MpCYP73A3 missing	sequence comparator	Third, lowly expressed MpCYP73A paralog contributing to redundancy that prevents full pathway abolition in single mutants.
Mp6g11010	MpACTIN7	experimental tool	Reference gene (Mp6g11010) used to normalize CYP73 expression levels in RT-qPCR.
Mp3g23400	MpEF1	experimental tool	Reference gene (Mp3g2340) used alongside MpACT7 to normalize expression in RT-qPCR.