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The Evolutionary Journey of the Sterol Synthesis Pathways in Eukaryotes

Ferreira-Guerra M, Coleto-Alcudia V, Mora-Garcia S, I Cano-Delgado A. · 2025 · Plant & cell physiology   research

doi:10.1093/pcp/pcaf016   PMID:40176736

Linked genes (7)  0 core 7 peripheral

Gene ID Name Evidence / Role Function (this paper)
Mp6g19120 MpCYP710-like sequence subject Mp6g19120 (MpCYP710A2) is a second Marchantia C-22 desaturase falling in a Marchantiales-specific CYP710A clade, sharing 52% identity with AtCYP710A1.
Mp1g00490 MpCYP710A16 sequence subject Mp1g00490 (MpCYP710A1) is identified as a Marchantia C-22 desaturase (CYP710A) homolog, sharing 55% identity with AtCYP710A1 and 64% with PpCYP710A13 in the phylogenetic analysis.
Mp5g20140 MpDWF1 sequence subject In the paper's phylogenetic analysis of bryophyte sterol enzymes, Mp5g20140 (MpDWF1A) clusters with SSR1/SSR2/24-ISO sequences and shares 72% identity with AtDWF1, placed as a Marchantia C-24 sterol reductase homolog.
Mp1g14660 MpDWF1-like sequence subject Mp1g14660 (MpDWF1B) is the second Marchantia DWF1-type sequence in the analysis, sharing 54% identity with AtDWF1, distinguished from MpDWF1A by lower conservation.
MpBES1 missing citation background Cited as the Marchantia ortholog of the brassinosteroid-responsive transcription factor BES1/BZR.
MpDWF5A missing citation background Cited as the Marchantia DWF5 homolog (closest to AtDWF5) functionally studied in prior work, expressed throughout the life cycle.
MpDWF5B missing citation background Cited bryophyte-lineage-specific DWF5 paralog reported unable to reduce the C-7 position of dehydrocholesterol.