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Comprehensive analysis of the INDETERMINATE DOMAIN (IDD) gene family in Marchantia polymorpha brings new insight into evolutionary developmental biology.

Zhou C, Yang T, Cai M, Cui H, Yu F, Liu H, Fu J. · 2025 · BMC Genomics   research

doi:10.1186/s12864-025-11609-7   PMID:40301722   PMC12039213

Linked genes (13)  7 core 6 peripheral

Gene ID Name Evidence / Role Function (this paper)
MpIDD1 missing experimental subject One of seven MpIDD family members identified and characterized. Expression analysis showed MpIDD1 is most abundant in the meristem and is downregulated by ABA; it interacts with MpGRAS3/MpSCR in yeast two-hybrid assays.
MpIDD2 missing experimental subject MpIDD family member whose expression is specific to gemma cups and strongly induced by IAA (auxin) treatment; interacts with MpGRAS3/MpSCR, suggesting a role in gemma cup development.
MpIDD3 missing experimental subject MpIDD family member that retains the conserved SHR-binding motif and was the strongest interactor of MpGRAS8/MpSHR in yeast two-hybrid assays, implicating it in a conserved SHR/IDD module.
MpIDD4 missing experimental subject MpIDD family member analyzed for phylogeny, structure, expression and interactions; interacted only weakly with MpGRAS8/MpSHR in this study.
MpIDD5 missing experimental subject MpIDD family member showing very high expression in rhizoids; interacted only weakly with MpGRAS8/MpSHR in yeast two-hybrid assays.
MpIDD6 missing experimental subject MpIDD family member (also named MpWIP) belonging to branch VI; highly expressed in gemmae and meristem, with its promoter previously reported active in developing air pores.
MpIDD7 missing experimental subject MpIDD family member whose expression is markedly elevated by MeJA and cytokinin treatments; the authors suggest it may promote flowering-related processes.
Mp1g10440 MpGRAS3 experimental comparator M. polymorpha SCR ortholog (MpGRAS3/MpSCR) used in interaction assays; confirmed interactions with MpIDD1 and MpIDD2.
Mp1g22880 MpGRAS8 experimental comparator M. polymorpha SHR ortholog (MpGRAS8/MpSHR) used in yeast two-hybrid interaction assays; interacted strongly with MpIDD3.
MpSCR missing sequence comparator SCR-ortholog designation for MpGRAS3 based on closest homology to Arabidopsis AtSCR.
MpSHR missing sequence comparator SHR-ortholog designation for MpGRAS8 based on homology to Arabidopsis AtSHR.
MpEF1a missing experimental tool Used as the internal reference gene for qRT-PCR normalization.
Mp1g09500 MpWIP citation background Alternative name for MpIDD6, cited for its previously reported function in air pore development.