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Protection of naringenin chalcone by a pathogenesis-related 10 protein promotes flavonoid biosynthesis in Marchantia polymorpha.

Zhou Y, Hamiaux C, Andre CM, Cooney JM, Schwinn KE, van Klink JW, Bowman JL, Davies KM, Albert NW. · 2025 · The New phytologist   research

doi:10.1111/nph.70194   PMID:40325841   PMC12138178

Linked genes (18)  3 core 15 peripheral

Gene ID Name Evidence / Role Function (this paper)
Mp6g05290 MpCHI experimental subject Chalcone isomerase. Mpchi mutants (and Mpchi-chil double mutants) were analyzed by RNAseq in this work for comparison with Mppr10.5; CHI was among flavonoid genes downregulated in Mppr10.5.
Mp5g01410 MpCHIL experimental subject Chalcone isomerase-like. Mpchil and Mpchi-chil double mutants were generated/analyzed here, showing limited differential expression; CHIL was downregulated in Mppr10.5 mutants.
Mp8g00860 MpPR10.5 experimental subject Primary subject. The Mp8g00860 ORF (149 aa) was classified in the PR10 family and named MpPR10.5. CRISPR/Cas9 mutants and metabolite-binding assays showed MpPR10.5 binds and protects naringenin chalcone; loss of function downregulates flavonoid biosynthesis genes, demonstrating it promotes flavonoid biosynthesis.
Mp1g01300 MpHDAC1 experimental tool Reference/housekeeping gene used to normalize qPCR/expression data.
Mp2g05850
MpAS1 paper
MpAUS nomenclature
experimental background Aureusidin synthase; downregulated in Mppr10.5 RNAseq.
Mp6g00020
MpC4H paper
MpC4H1 nomenclature
experimental background Highest-abundance C4H, transcript level unchanged in Mppr10.5.
Mp8g05080 MpC4H3 experimental background Cinnamate 4-hydroxylase; downregulated in Mppr10.5 RNAseq.
MpCHS13 missing experimental background Chalcone synthase downregulated in Mppr10.5 RNAseq.
MpCHS17 missing experimental background Highest-abundance CHS, transcript level unchanged in Mppr10.5.
MpCHS2 missing experimental background Chalcone synthase downregulated in Mppr10.5 RNAseq.
Mp1g20080 MpDBR experimental background Bis-bibenzyl biosynthetic gene, unaffected in Mppr10.5.
MpMYB14 missing citation background Auronidin/flavonoid transcriptional regulator; cited prior 35S:MYB14 and Mpmyb14 lines showing MpPR10.5 is a MpMYB14 target.
Mp4g14160 MpPAL-like2 experimental background PAL-like gene downregulated in Mppr10.5 RNAseq.
Mp1g10150 MpPAL1 experimental background Phenylalanine ammonia-lyase; downregulated in Mppr10.5 RNAseq.
MpPKR missing experimental background Bis-bibenzyl biosynthetic gene, unaffected in Mppr10.5.
Mp5g07330 MpPR10.3 citation background PR10 family member; cited UVB-responsive expression pattern.
Mp8g08940 MpPR10.9 citation background PR10 family member; cited UVB-responsive expression pattern.
Mp7g14930 MpSTCS1A experimental background Bis-bibenzyl biosynthetic gene, unaffected in Mppr10.5.