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Shikimate Kinase-Like 1 Participates in an Ancient and Conserved Role Contributing to Chloroplast Biogenesis in Land Plants.

Kanaris M, Lee J, Chang B, Christendat D. · 2025 · Molecular biology and evolution   research

doi:10.1093/molbev/msaf129   PMID:40452216   PMC12203367

Linked genes (4)  2 core 2 peripheral

Gene ID Name Evidence / Role Function (this paper)
Mp3g21830 MpSK1 experimental subject MpSK (Mp3g21830) was identified as a shikimate kinase homolog; enzyme kinetic assays showed it phosphorylates shikimate, confirming it is a functional SK.
Mp6g03600 MpSK2 experimental subject CRISPR/Cas9 disruption of MpSKL1 (Mp6g03600) caused pigment-defective phenotypes, reduced growth and pale tissue, with abnormal chloroplast/thylakoid morphology and reduced chlorophyll a/b. Heterologous AtcTP-delta80MpSKL1 also rescued chloroplast biogenesis in Arabidopsis skl1-8, supporting a conserved role in chloroplast biogenesis.
Mp3g23400 MpEF1 experimental tool Used as a housekeeping/internal control gene for expression analysis.
Mp3g07860 missing sequence background Third M. polymorpha SK gene homolog, identified by sequence as separating among SKL2 sequences; not functionally characterized here.