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Electrostatic changes enabled the diversification of an exocyst subunit via protein complex escape.

De la Concepcion JC, Duverge H, Kim Y, Julian J, Xu HD, Watt MN, Ikene SA, Bianchi A, Grujic N, Papareddy RK, Grishkovskaya I, Haselbach D, Murray DH, Clavel M, Irwin NAT, Dagdas Y. · 2025 · Nature plants   research

doi:10.1038/s41477-025-02135-1   PMID:41174228   PMC12626893

Linked genes (7)  7 core 0 peripheral

Gene ID	Name	Evidence / Role	Function (this paper)
—	MpExo70I missing	experimental subject	The paper experimentally characterizes MpExo70I as a representative of the plant Exo70 family I. It localizes to the cell plate in postmitotic cells and assembles into the core exocyst, binding MpExo84 and forming the subcomplex MpSEC15:MpSEC10:MpExo84:MpExo70I, illustrating canonical exocyst incorporation.
—	MpExo70II missing	experimental subject	MpExo70II (Exo70 family II) was experimentally studied and showed diffuse localization distinct from the cell plate and a broader, divergent interactome, contrasting with the core-exocyst-associated MpExo70I and supporting functional diversification of Exo70 subunits.
—	MpExo70III missing	experimental subject	MpExo70III represents plant Exo70 family III and was experimentally characterized; like MpExo70I it localized to the cell plate in postmitotic Marchantia cells.
—	MpExo84 missing	experimental subject	MpExo84 was extensively studied by Y2H, co-IP and biochemistry as the primary interactor of MpExo70I, hetero-dimerizing with Exo70 at the exocyst core and accumulating at the cell plate, defining the Exo84-Exo70 interaction central to exocyst assembly and its diversification.
—	MpSEC10 missing	experimental subject	MpSEC10 is a core exocyst subunit reconstituted in purified Marchantia exocyst subcomplexes (MpSEC15:MpSEC10:MpExo84:MpExo70I), used to dissect subunit assembly and Exo70 incorporation.
—	MpSEC15 missing	experimental subject	MpSEC15, a core exocyst subunit, was part of the purified Marchantia exocyst subcomplexes used to reconstitute and characterize exocyst assembly and Exo70 binding.
—	MpSEC6 missing	experimental subject	MpSEC6, a core exocyst subunit, was experimentally shown to accumulate at the cell plate alongside MpExo84, supporting assembly of a functional Marchantia exocyst at the division plane.