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Plant-fungi interactions in Marchantia polymorpha are associated with horizontal gene transfer and terpene metabolism.

El Mahboubi K, Beaulieu C, Castel B, Libourel C, Jariais N, Amblard E, van Beveren F, Keller J, Martinez Y, Nelson JM, Bonhomme M, Jacquet C, Delaux PM. · 2026 · Proceedings of the National Academy of Sciences of the United States of America   research

doi:10.1073/pnas.2532723123   PMID:41637459   PMC12890914

Linked genes (21)  6 core 15 peripheral

Gene ID Name Evidence / Role Function (this paper)
Mp6g04605 missing experimental subject MTPSL gene in the HGT-derived terpene synthase cluster associated with variation in fungal symptom severity.
Mp6g04610 MpFTPSL10 experimental subject MTPSL gene in the HGT-derived terpene synthase cluster associated with variation in fungal symptom severity.
Mp6g04580 MpFTPSL5 experimental subject Member of a cluster of five microbial-type terpene synthase (MTPSL) genes acquired by horizontal gene transfer from fungi; the cluster is associated with variation in fungal symptom severity. Attempted full-cluster deletion produced only chimeric thalli, preventing stable mutant lines.
Mp8g05270 MpLDPS2 experimental subject GWAS associated an association region on chromosome 8 with fungal symptom severity, flanked by an unannotated gene and MpLDPS2. MpLDPS2 encodes a protein with a 1,8-cineole synthase domain (converting geranyl pyrophosphate to 1,8-cineole/eucalyptol) plus an LDPS domain, implicating terpene metabolism in plant-fungi interaction.
Mp6g04630 MpMTPSL10 experimental subject MTPSL gene in the HGT-derived terpene synthase cluster of microbial terpene synthases acquired from fungi; the cluster is associated with fungal symptom severity in M. polymorpha.
MpMTPSL14 experimental subject MTPSL gene in the HGT-derived terpene synthase cluster on chromosome 6 associated with fungal symptom severity; targeted cluster deletion could not be stabilized.
Mp1g00650 missing experimental background Thioredoxin gene overlapping a chromosome-1 GWAS association signal for fungal symptom severity.
Mp2g20730 missing experimental background tRNA synthetase gene at a GWAS-associated locus for fungal symptom severity.
Mp5g15200 missing experimental background Orotidine 5'-decarboxylase gene at a GWAS-associated locus for fungal interaction.
Mp5g15210 missing experimental background Atypical ABC1K kinase gene at a GWAS-associated locus for fungal interaction.
Mp8g05260 missing experimental background Unannotated gene flanking the chromosome-8 GWAS association region for fungal symptom severity, adjacent to MpLDPS2.
Mp4g08800 LURP1 missing experimental background Defense-associated gene listed near GWAS signals for fungal symptom severity.
Mp2g00660 MpLOX1 experimental background Lipoxygenase (oxylipin synthesis) gene among genes implicated in the response to fungal interaction.
Mp1g21930 MpLOX5 experimental background Lipoxygenase gene noted among defense/oxylipin loci near GWAS association signals.
Mp4g08790 MpNBS-LRR11 experimental background Defense-related gene noted among loci near GWAS association signals for plant-fungi interaction.
Mp4g14110 MpPAL7 experimental background Phenylalanine ammonia-lyase among secondary-metabolite genes implicated in fungal interaction.
MpPKS missing experimental background Polyketide/chalcone synthase (PKS/CHS11) among secondary-metabolite genes implicated in fungal interaction.
Mp2g05790 MpPPO3 experimental background Polyphenol oxidase among secondary-metabolite genes implicated in fungal interaction.
Mp2g20720 MpRLK-Pelle_RLCK-XII-1 experimental background Receptor-like kinase gene at a GWAS-associated locus for fungal symptom severity.
Mp5g05560 MpWRKY3 experimental background WRKY transcription factor among genes implicated in the response to fungal interaction.
Mp3g17660 MpWRKY7 experimental background WRKY transcription factor among genes implicated in the response to fungal interaction.