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The SPL-family transcription factor MpSPL3 orchestrates the proper regulation of vegetative and reproductive programs in Marchantia polymorpha.

Alisha A, Jarmolowski A, Szweykowska-Kulinska Z, Sierocka I. · 2026 · The Plant journal : for cell and molecular biology   research

doi:10.1111/tpj.70755   PMID:41840856   PMC12993094

Linked genes (19)  13 core 6 peripheral

Gene ID Name Evidence / Role Function (this paper)
Mp8g11450 MpAP2L1 experimental subject MpANT/MpPLT, a meristem-development TF, showed the strongest downregulation among tested genes in Mpspl3 knockout mutants by qPCR in this study.
Mp1g07070 MpARF3 experimental subject MpARF3 (AUXIN RESPONSE FACTOR3) transcript level was unchanged in Mpspl3 knockout mutants by qPCR in this study, indicating it is not regulated by MpSPL3 despite a hypothesized role in inhibiting the reproductive transition.
Mp3g23300 MpBNB experimental subject MpBNB (BONOBO), involved in germ cell specification, was strongly downregulated in Mpspl3 knockout (and overexpression) plants by qPCR in this study.
Mp2g23000 MpBZR3 experimental subject MpBZR3 (BRASSINAZOLE-RESISTANT 3) was strongly downregulated in Mpspl3 knockout and overexpression mutants by qPCR here, linking MpSPL3 to far-red-responsive reproductive programs.
Mp2g02750 MpCKI1 experimental subject MpCKI1 (CYTOKININ-INDEPENDENT 1 histidine kinase), required for proper antheridiophore morphology, was significantly downregulated in Mpspl3 knockout mutants by qPCR here.
Mp7g09740 MpGARP8 experimental subject MpGLK (GOLDEN2-LIKE) mRNA was downregulated in Mpspl3 knockout mutants by qPCR here; it normally activates MpMAX2 to regulate gemma cup timing.
Mp2g11710 MpKAI2A experimental subject MpKAI2A, controlling gemma cup formation and gemma initiation, was downregulated in Mpspl3 knockout mutants by qPCR in this study.
Mp2g20695 MpLRL experimental subject MpLRL (LJRHL-LIKE), which stabilizes MpBNB, was significantly downregulated in Mpspl3 knockout mutants by qPCR in this study.
Mp3g05470 MpMIR529C experimental subject SPL-family gene downregulated in Mpspl3 knockout plants here, indicating MpSPL3 acts upstream of the miR529c-MpSPL2 module driving the vegetative-to-reproductive phase transition.
Mp7g17540 MpROP experimental subject MpROP (RHO OF PLANTS) mRNA was downregulated in Mpspl3 knockout mutants by qPCR here, linking MpSPL3 to rhizoid/meristem-related programs.
Mp1g10020 MpSPL1 experimental subject SPL-family gene found significantly downregulated in Mpspl3 knockout mutants in this study, placing it downstream of MpSPL3 in coordinating meristem dormancy.
Mp1g13640 MpSPL3 experimental subject Primary subject. The SPL-family TF MpSPL3 produces two splice isoforms (MpSPL3.1 longer by 183 nt due to in-frame intron 3 retention; MpSPL3.2). amiR knockout of both transcripts causes complete loss of gametangiophore formation, while overexpression of MpSPL3.1 delays and reduces gametangiophore production, showing MpSPL3 coordinates vegetative growth and the reproductive phase transition.
Mp8g11850 MpSPL4 experimental subject AtSPL7-like SPL gene whose expression was downregulated in Mpspl3 knockout mutants under white light in this study, placing it downstream of MpSPL3.
Mp3g23400 MpEF1 experimental tool MpEF1α was used as the reference gene for RT-qPCR normalization in this study.
Mp1g26670 MpMIR160 experimental tool The MpmiR160 precursor backbone was used as the scaffold for the artificial miRNA designed to knock down MpSPL3.
Mp1g02580 MpMAX2 citation background Cited from prior work as a gene activated by MpGLK to regulate gemma cup timing.
Mp6g07990 Mpo-MR-13 missing citation background Liverwort-specific miRNA (MpmiR11671) cited as regulating MpSPL1 in meristem dormancy.
Mp3g06310 MpSMXL citation background Cited from prior work as part of the KAI2-dependent signaling pathway.
Mp8g08780 MpYUC2 citation background Mentioned as background in the context of auxin biosynthesis gene regulatory networks.