MarpolBase - A simple cell-cycle control system in Marchantia polymorpha provides a framework for understanding plant cell proliferation

A simple cell-cycle control system in Marchantia polymorpha provides a framework for understanding plant cell proliferation

Romani, F., et al. · 2026 · The Plant Cell research

doi:10.1093/plcell/koag103 PMID:41967031 PMC13237563

Linked genes (23) 8 core 15 peripheral

Gene ID	Name	Evidence / Role	Function (this paper)
Mp2g04270	MpCDKA	experimental subject	CDKA cyclin-dependent kinase; core CDK of the simple Marchantia cell-cycle system.
Mp5g19170	MpCDKB	experimental subject	Plant-specific CDKB; G2/M-associated CDK of the core set.
Mp2g25500	MpCYCA	experimental subject	A-type cyclin; phase-specific at S/G2. Overexpression causes growth arrest, consistent with a role at the S-phase/G2 transition.
Mp5g10030	MpCYCB_1	experimental subject	B-type cyclin; predominant G2/M cyclin. Overexpression causes growth arrest; protein turnover/localization contribute to phase specificity.
Mp2g00590	MpCYCB_2	experimental subject	Second B-type cyclin; phase-specific expression around G2/M (scRNA-seq + live imaging).
Mp8g17230	MpCYCD_1	experimental subject	D-type cyclin; predominant G1/S cyclin. Overexpression is sufficient to promote cell-cycle re-entry — a key driver of proliferation in the reduced, nonredundant Marchantia cell-cycle system.
Mp1g24670	MpCYCD_2	experimental subject	Second D-type cyclin; expression profiled across cell-cycle phases.
Mp3g00300	MpKRP	experimental subject	KIP-RELATED PROTEIN; CDK inhibitor of the nonredundant core cell-cycle system.
Mp3g00030	MpCDC20_1	experimental comparator	CDC20/APC activator; mitotic-exit component.
Mp1g15730	MpCDC20_2	experimental comparator	CDC20 paralog; gene inventory.
Mp4g01900	MpCDC25_1	experimental comparator	CDC25-like phosphatase; phase expression analysed.
Mp1g01430	MpCDC25_2	experimental comparator	CDC25-like phosphatase paralog; gene inventory.
Mp5g04400	MpCDKC;1 missing	experimental comparator	CDKC-type kinase; included in the cell-cycle gene survey.
Mp5g02990	MpCDKC;2 missing	experimental comparator	CDKC-type kinase paralog; gene survey.
—	MpCKS missing	experimental comparator	CDK subunit (CKS); cell-cycle gene inventory.
Mp3g20990	MpDEL1	experimental comparator	DEL/E2F-like factor; cell-cycle gene inventory.
Mp5g07890	MpDEL2	experimental comparator	DEL/E2F-like factor; cell-cycle gene inventory.
Mp3g12060	MpDP1	experimental comparator	DP dimerization partner of E2F; phase expression in the core set.
Mp4g07910	MpDP2	experimental comparator	DP-family member; cell-cycle gene inventory.
Mp4g06740	MpDP3	experimental comparator	DP-family member; cell-cycle gene inventory.
Mp1g02890	MpE2F	experimental comparator	E2F transcription factor (E2F-DP-RBR module); part of the surveyed core cell-cycle gene set.
Mp1g27090	MpWEE1	experimental comparator	WEE1 kinase; G2/M checkpoint component of the core set.
—	MpH3.1 missing	experimental tool	Replication-dependent histone H3.1; used as an S-phase/proliferation marker (reporter).