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An adenylyl cyclase with a phosphodiesterase domain in basal plants with a motile sperm system.

Kasahara, M., et al. · 2016 · Scientific Reports   research

doi:10.1038/srep39232   PMID:27982074   PMC5159850

Linked genes (1)  1 core 0 peripheral

Gene ID	Name	Evidence / Role	Function (this paper)
Mp7g08500	MpCAPE	experimental subject	Cloned from Marchantia as a fusion protein with an N-terminal cyclic-nucleotide phosphodiesterase domain and a C-terminal class III adenylyl cyclase domain; recombinant GST-MpCAPE-AC produced cAMP (Mn2+ enhancing activity ~35-fold over Mg2+) and complemented an E. coli AC-deficient mutant, while His-MpCAPE-PDE hydrolyzed cAMP/cGMP, with catalytic residues (Asp-1340 for AC; His-199/203 for PDE) confirmed essential by mutagenesis. GUS reporter showed expression in the antheridium, implicating it in male reproductive development.