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TALEN-mediated genome-editing approaches in the liverwort Marchantia polymorpha yield high efficiencies for targeted mutagenesis.

Kopischke, S., et al. · 2017 · Plant Methods   research

doi:10.1186/s13007-017-0167-5   PMID:28360929   PMC5370431

Linked genes (2)  1 core 1 peripheral

Gene ID Name Evidence / Role Function (this paper)
Mp8g11800 MpNOP1 experimental subject Selected as the TALEN knockout target because its mutant lacks air chamber formation (an easily traceable phenotype); both TALEN approaches achieved >20% targeting efficiency with deletions of 4 nt to ~2000 nt across 22 sequenced T1 lines. Two mutants carried in-frame indels revealing novel Mpnop1-related phenotypes, with stable inheritance across generations.
Mp3g23400 MpEF1 experimental tool Its characterized, strongly expressed endogenous promoter was used in both binary vectors to drive TALEN expression in Marchantia tissues including meristematic regions.