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SARS-CoV-2 Fears Green- The Chlorophyll Catabolite Pheophorbide A Is a Potent Antiviral.

Jimenez-Aleman, G. H., et al. · 2021 · Pharmaceuticals   research

doi:10.3390/ph14101048   PMID:34681272   PMC8538351

Linked genes (2)  2 core 0 peripheral

Gene ID Name Evidence / Role Function (this paper)
Mp3g02320 MpC1HDZ experimental subject The Mpc1hdz mutant, impaired in oil body formation and thus defective in secondary metabolite accumulation, was tested in antiviral assays. Extracts still showed clear protective activity below cytotoxic doses, indicating the antiviral metabolite is independent of oil-body secondary metabolism.
Mp2g26590 MpCOI1 experimental subject The Mpcoi1-2 mutant, impaired in dn-OPDA (jasmonate) perception and thus in defense metabolite induction, was tested in viral assays. Extracts retained antiviral activity, supporting that the active compound (pheophorbide A) derives from primary rather than jasmonate-dependent secondary metabolism.