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DELLA proteins recruit the Mediator complex subunit MED15 to coactivate transcription in land plants.

Hernández-García, J., et al. · 2024b · Proceeding of the National Academy of Sciences USA   research

doi:10.1073/pnas.2319163121   PMID:38696472   PMC11087773

Linked genes (4)  3 core 1 peripheral

Gene ID Name Evidence / Role Function (this paper)
Mp5g20660 MpGRAS6 experimental subject Tested by yeast two-hybrid, BiFC, and dual-luciferase assays; its N-terminal domain bound the MpMED15 KIX domain and its GRAS domain bound MpMYB14. Acts as a transcriptional coactivator, enhancing MpMYB14-driven MpPAL activation, demonstrating conserved DELLA-MED15 coactivation in land plants.
Mp8g02180 MpMED15 missing experimental subject Identified as the single full-length MED15 gene in M. polymorpha; its KIX domain interacted with MpDELLA's N-terminus by Y2H/BiFC and coexpression in luciferase assays further boosted MpMYB14/MpDELLA-dependent MpPAL activation, supporting conserved Mediator recruitment.
Mp5g19050 MpR2R3-MYB14 experimental subject Shown by Y2H and BiFC to interact with MpDELLA via its GRAS domain; in dual-luciferase assays it activated the MpPAL promoter, with this activity enhanced by MpDELLA and further by MpMED15 in a gene-specific manner.
Mp1g05190
MpPAL paper
MpPAL10 nomenclature
experimental tool Its promoter was used as a luciferase reporter target to assay MpMYB14/MpDELLA/MpMED15 coactivation.