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The BNB–GLID module regulates germline fate determination in Marchantia polymorpha.

Ren, X., et al. · 2024 · Plant Cell   research

doi:10.1093/plcell/koae206   PMID:39041486   PMC11371191

Linked genes (8)  2 core 6 peripheral

Gene ID Name Evidence / Role Function (this paper)
Mp3g23300 MpBNB experimental subject bHLH transcription factor (Mp3g23300) acting upstream of MpGLID to dictate germline fate entry; overexpression induces male germ cell-like cells. Y1H and EMSA show MpBNB directly binds and activates the MpGLID promoter.
Mp3g17000 MpGLID experimental subject PHD finger protein (Mp3g17000) preferentially expressed early in antheridia; loss-of-function fails to specify sperm cells and overexpression induces ectopic male germline cells. Acts as a master regulator of both male and female germline specification, directly activated by MpBNB via an E-box (CACGTG) in its promoter.
Mp3g06700 missing experimental comparator Antheridium-specific PHD subclade II gene peaking at late stage; loss-of-function mutants showed no effect on male gametogenesis, contrasting MpGLID.
Mp7g08500 MpCAPE experimental tool Antheridium-expressed gene used as a marker; activated in MpGLID-overexpressing transgenics.
Mp5g07890 MpDEL2 experimental tool Antheridium-expressed gene used as a marker; activated in MpGLID-overexpressing transgenics.
Mp3g23400 MpEF1 experimental tool MpEF1alpha promoter used as the constitutive promoter for transgenic overexpression constructs.
Mp2g23000 MpBZR3 experimental background BZR/BES TF gene, an early antheridium-specific marker essential for early antheridium development and upregulated in MpGLID-overexpressing plants.
Mp2g20695 MpLRL citation background Cited alongside CKI1 as securing specific, stable expression of MpBNB.