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MID1- COMPLEMENTING ACTIVITY regulates cell proliferation and development via Ca2+ signaling in Marchantia polymorpha.

Iwano, M., et al. · 2024 · Plant Physiology   research

doi:10.1093/plphys/kiae613   PMID:39535860   PMC11663713

Linked genes (2)  1 core 1 peripheral

Gene ID Name Evidence / Role Function (this paper)
Mp5g19510 MpMCA missing experimental subject Single MCA ortholog (Mp5g19510) characterized as the main subject; MpMCA-promoter GUS/Citrine reporters, CRISPR Mpmca knockouts, YC3.60 Ca2+ imaging, and Arabidopsis MCA1 complementation were used. It is a plasma-membrane protein expressed in the notch/dividing cells and reproductive organs; mutants show severe cell proliferation/differentiation defects and reduced cytoplasmic Ca2+, so MpMCA regulates Ca2+-dependent cell proliferation and sexual reproduction.
Mp8g17230 MpCYCD_1 experimental tool D-type cyclin used as a cell-division marker by RT-qPCR; its expression was significantly lower in Mpmca than wild type, indicating reduced cell proliferation.