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A conserved ARF–DNA interface underlies auxin-triggered transcriptional response.

Rienstra, J., et al. · 2025 · Proceeding of the National Academy of Sciences USA   research

doi:10.1073/pnas.2501915122   PMID:40168121   PMC12002309

Linked genes (4)  2 core 2 peripheral

Gene ID Name Evidence / Role Function (this paper)
Mp1g12750 MpARF1 experimental subject Functionally studied as the sole A-class positive effector of auxin transcription: alanine substitutions (R194, P197, R199) and B3-domain swaps were assayed for complementation of the Mparf1-4 null. RNA-seq showed Tak-1 responded to IAA (112 DEGs) while Mparf1 showed no auxin response, defining R194/P197/R199 as essential for its DNA-binding function.
Mp1g07070 MpARF3 experimental subject C-class ARF assessed by complementation: its DBD failed and its B3 domain only partially complemented Mparf1-4, indicating C-class DNA-binding specificity diverged early; B3 is entirely conserved across accessions.
Mp4g11820 MpARF2 experimental comparator B-class ARF whose B3 domain was used for structural/docking comparison and swapped into MpARF1, fully complementing the Mparf1 mutant (functionally similar B3).
MpAPT3 missing experimental tool Reference gene used for RT-qPCR normalization (primers JR163/JR164).