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ARF degradation defines a deeply conserved step in auxin response.

de Roij M, Hernandez Garcia J, Das S, Borst JW, Weijers D. · 2025 · Nature plants   research

doi:10.1038/s41477-025-01975-1   PMID:40216983   PMC12014493

Linked genes (3)  3 core 0 peripheral

Gene ID	Name	Evidence / Role	Function (this paper)
Mp1g12750	MpARF1	experimental subject	Experimentally studied. The A-class ARF MpARF1 protein is likewise shown to be unstable, and degradation-motif swap experiments confirm it shares the conserved degradation determinants characterized for MpARF2.
Mp4g11820	MpARF2	experimental subject	Primary subject. Using NLS-mNG fusions expressed from its own promoter, the authors show the B-class ARF MpARF2 protein is unstable and degraded via the 26S proteasome, and identify a minimal motif in the DNA-binding domain (residues E297, S299, R300) necessary for this conserved degradation step in auxin response.
Mp1g07070	MpARF3	experimental subject	Experimentally tested as a stable contrast: the C-class ARF MpARF3 protein is stable in its native context, used to demonstrate that the degradation behavior is specific to A- and B-class ARFs.