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The MpANT-Auxin Loop Modulates Marchantia polymorpha Development.

Melissa DÁ, Luis LJ, Eduardo FS, Annie EC, Domingo MÁ, Tom FJ, Jesús LR, Fernando OM, John BL, Mario AA, Cruz-Ramírez A. · 2025 · Physiologia plantarum   research

doi:10.1111/ppl.70365   PMID:40583831   PMC12207571

Linked genes (31)  14 core 17 peripheral

Gene ID Name Evidence / Role Function (this paper)
Mp6g08530 missing experimental subject One of three M. polymorpha AGC kinases (closest to AtPINOID) implicated in MpPIN1 phosphorylation; expression examined by RT-qPCR.
Mp8g11302 missing experimental subject One of three M. polymorpha AGC kinases (closest to AtPINOID) implicated in MpPIN1 phosphorylation; expression examined by RT-qPCR.
Mp8g16840 missing experimental subject One of three M. polymorpha AGC kinases (closest to AtPINOID) implicated in MpPIN1 phosphorylation; expression examined by RT-qPCR.
Mp8g11450 MpAP2L1 experimental subject The sole AINTEGUMENTA-LIKE/PLT/BBM ortholog in M. polymorpha and the central subject. Using transcriptional fusions, auxin (2,4-D/NPA) treatments, 35S:MpANT-CITRINE overexpression, CRISPR loss-of-function, RT-qPCR, immunolocalization and EdU assays, MpANT was shown to be auxin-induced and meristem-enriched; loss-of-function reduced plant size, meristematic activity and rhizoids while overexpression expanded proliferative areas. MpANT acts upstream of MpPIN1, forming an auxin-MpANT-MpPIN1 feedforward loop.
Mp1g12750 MpARF1 experimental subject Auxin response factor in the MpANT co-expression cluster; moderately downregulated in MpANT loss-of-function by RT-qPCR.
Mp4g11820 MpARF2 experimental subject Auxin response factor co-expressed with MpANT and assessed in the RT-qPCR expression analysis of MpANT mutants.
Mp1g07070 MpARF3 experimental subject Auxin response factor in the MpANT co-expression cluster; moderately downregulated in MpANT loss-of-function by RT-qPCR.
MpCYCD missing experimental subject D-type cyclin associated with cell proliferation; expression examined by RT-qPCR as a candidate MpANT-regulated proliferation gene.
Mp1g10440 MpGRAS3 experimental subject GRAS-family gene linked to cell proliferation/meristem maintenance; a putative MpANT target whose expression was examined by RT-qPCR in MpANT mutants.
Mp3g21660 MpPIN1 experimental subject Auxin-efflux transporter analyzed as a major MpANT target. RT-qPCR and PIN1 immunolocalization showed MpANT modulates MpPIN1 expression/localization and auxin distribution; an APB-binding site is present in the MpPIN1 promoter.
Mp5g05140 MpPIN2 experimental subject Auxin-efflux transporter whose expression was examined by RT-qPCR in MpANT mutants.
Mp5g14320 MpTAA experimental subject Auxin-biosynthesis (TAA) gene; a putative MpANT target carrying an APB-binding site in its promoter and moderately downregulated in MpANT loss-of-function by RT-qPCR.
Mp5g07790 MpYUC1 experimental subject Auxin-biosynthesis (YUCCA) gene examined by RT-qPCR; moderately downregulated in MpANT loss-of-function mutants.
Mp8g08780 MpYUC2 experimental subject Auxin-biosynthesis (YUCCA) gene co-expressed with MpANT and examined by RT-qPCR; moderately downregulated in MpANT loss-of-function.
MpACT7 missing experimental tool Used as the internal reference gene for RT-qPCR normalization.
Mp8g09250 MpASLBD17 citation background Co-expressed with MpANT in the young sporophyte region.
Mp4g12420 MpBHLH44 citation background Co-expressed with MpANT in antheridia/archegonia regions.
Mp2g03050 MpCHK1 citation background Co-expressed with MpANT in antheridia/archegonia regions.
Mp6g07050 MpCLE1 citation background Cited from Liu et al. as a transcriptional target through which MpANT restricts cell proliferation.
Mp1g02840
MpDCL3 paper
MpDCL1a nomenclature
citation background Co-expressed with MpANT in antheridia/archegonia regions.
Mp5g21990 MpGRAS9 citation background Cited from Liu et al. as a direct MpANT target.
Mp8g16900 MpGRF citation background Growth-regulating factor co-expressed with MpANT in apical cells.
Mp6g05000 MpIAA citation background Aux/IAA auxin-signaling gene mentioned in the MpANT co-expression cluster.
Mp1g02860 MpLFY citation background Co-expressed with MpANT in antheridia/archegonia regions.
Mp4g11760 MpMADS2 sequence background MIKCc-type MADS-box gene proposed as a putative MpANT target via APB-binding-site/co-expression inference.
Mp8g17460 MpPYL1 sequence background ABA-receptor gene most strongly co-expressed with MpANT and proposed as a putative target.
MpRDR5 missing citation background Co-expressed with MpANT in the young sporophyte region.
MpRDR6-2 missing citation background Co-expressed with MpANT in the young sporophyte region.
Mp3g19510 MpSHI citation background SHI-related gene noted in the MpANT co-expression cluster.
Mp1g10030 MpSPL2 sequence background SPL-like transcription factor proposed as a putative MpANT target based on co-expression and APB-binding-site inference.
Mp1g11660 MpWOX citation background Cited from Fu et al. as a downstream gene by which MpANT promotes meristem maintenance.