← Literature list

PKL mediates H3K4me2 modification and spatial gene congregation in chromatin regulation.

Song M, Wang Y, Ma T, Terzaghi W, He K, Wang H, Xu B, Jing Y, Lin R, Deng XW, Zhu D, Wang Y. · 2025 · Nucleic acids research   research

doi:10.1093/nar/gkaf1376   PMID:41359383   PMC12684393

Linked genes (6)  6 core 0 peripheral

Gene ID Name Evidence / Role Function (this paper)
Mp4g00040 Mp1R-MYB20 experimental subject PICKLE-LIKE 2, a Marchantia PKL homolog. A CRISPR pll2 mutant was generated and showed growth defects and DEGs overlapping pll1/pll3. APA of Hi-C data showed TCP1-distal-targeted histone-modified regions were spatially aggregated in WT but dispersed in the pll2 mutant. MpPLL2 also interacts with MpTCP1, MpHY5 and MpPIF by Y2H.
Mp1g16800
MpHY5 paper
MpBZIP1 nomenclature
experimental subject Marchantia HY5 transcription factor shown by Y2H to interact with MpPLL1 and MpPLL2, supporting conserved partnership of liverwort PKL homologs with this TF.
Mp3g17350 MpPIF experimental subject Marchantia PIF transcription factor shown by Y2H to interact with MpPLL1 and MpPLL2, supporting conserved partnership of liverwort PKL homologs with this TF.
Mp5g24460 Mpsnf1.17 experimental subject PICKLE-LIKE 1, a Marchantia PKL homolog identified by sequence similarity. Authors generated a CRISPR pll1 mutant; transcriptome profiling showed DEGs largely overlapping with pll2/pll3, supporting functional redundancy. Y2H showed MpPLL1 interacts with MpTCP1, MpHY5 and MpPIF, indicating conserved cooperation of liverwort PKL homologs with these TFs.
Mp1g05480 Mpsnf1.2 experimental subject PICKLE-LIKE 3, a Marchantia PKL homolog. A CRISPR pll3 mutant was generated and exhibited growth defects, with DEGs largely overlapping pll1/pll2, supporting redundancy among the three liverwort PKL homologs.
Mp7g01530 MpTCP1 missing experimental subject Marchantia TCP transcription factor. ChIP showed MpTCP1 binding enriched around TSS; in a tcp1 mutant the spatial aggregation of TCP1-distal-targeted histone-modified regions was lost (dispersed), paralleling the pll2 mutant, indicating MpPLL/MpTCP1 cooperate in spatial chromatin congregation. MpTCP1 also interacts with MpPLL1/MpPLL2 by Y2H.