Mp5g18040



Description

Annotation

Database ID Description
MobiDBLite mobidb-lite consensus disorder prediction
SUPERFAMILY SSF82199 SET domain
ProSiteProfiles PS50280 SET domain profile.
Pfam PF00856 SET domain
CDD cd10519 SET_EZH
PANTHER PTHR45747 HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)
Gene3D G3DSA:2.170.270.10 SET domain
ProSiteProfiles PS51576 Histone-lysine N-methyltransferase (EC 2.1.1.43) family profile.
FunFam G3DSA:2.170.270.10:FF:000001 Putative histone-lysine N-methyltransferase EZH2
Pfam PF18264 CXC domain
ProSiteProfiles PS51633 CXC domain profile.
SMART SM00317 set_7
Coils Coil Coil
SMART SM01114 CXC_2
KOG KOG1079 Transcriptional repressor EZH1; N-term missing; [K]
KOG KOG1079 Transcriptional repressor EZH1; C-term missing; [K]
KOG KOG1015 Transcription regulator XNP/ATRX, DEAD-box superfamily; C-term missing; [K]
MapolyID Mapoly0084s0051 -
GO GO:0031519 PcG protein complex
GO GO:0005634 nucleus
GO GO:0006338 chromatin remodeling
GO GO:0005515 protein binding
GO GO:0031507 heterochromatin formation
GO GO:0042054 histone methyltransferase activity
GO GO:0046976 histone H3K27 methyltransferase activity
GO GO:0003682 chromatin binding

Nomenclature

Gene symbol Product Transcript ID Status
MpCXC3 transcription factor, CXC Published
MpE(z)1 E(z)1 Published

Associated Literature (AI-based literature mining, Beta-version)

MpE(z)1 (Enhancer of zeste homolog) is the catalytic PRC2 subunit; the Mpknox2 Mpe(z)1 double mutant with reduced PRC2 activity was analysed by ChIP, showing depletion of H3K27me3 at facultative-heterochromatin states while H2Aub was retained.

2 core 2 peripheral

Shukla V, Axelsson E, Hisanaga T, Haseloff J, Berger F, Romani F. (2026) · PLoS genetics  research experimental subject
MpE(z)1 (Enhancer of zeste homolog) is the catalytic PRC2 subunit; the Mpknox2 Mpe(z)1 double mutant with reduced PRC2 activity was analysed by ChIP, showing depletion of H3K27me3 at facultative-heterochromatin states while H2Aub was retained.
Hisanaga, T., et al. (2023a) · Current Biology  research experimental subject
E(z)/EZH PRC2 catalytic subunit (MpE(z)1, Mp5g18040); the only E(z) paralog expressed in vegetative gametophyte; knockout shows PRC2 deposits H3K27me3 and represses TEs and developmental genes.
Montgomery, S. A., et al. (2022) · eLife  research experimental comparator
Expressed in all tissues including embryos; not functionally knocked out due to haploid lethality, so likely accounts for residual H3K27me3 in e(z)2/e(z)3 mutants, indicating redundancy among PRC2 catalytic subunits.
Dierschke, T., et al. (2021) · eLife  research experimental tool
Used as a knockdown transgene/experimental construct serving as a comparison control rather than a focus of study.

Expression Level powered by MBEX

Link to the original image in MBEX

Transcript models

Transcript ID Location Sequences Extract region
Mp5g18040.1 chr5:22261104..22271641 (+) Gene /  mRNA /  CDS /  Protein
FASTA / GenBank (with flanking bases)

Gene structure:

Sequences:

Gene UTR + CDS + intron

FASTA

mRNA UTR + CDS

FASTA

CDS

FASTA

Protein

FASTA


MarpolBase / Genome Informatics Lab. NIG.