MpUg00370



Description

Annotation

Database ID Description
Pfam PF06217 GAGA binding protein-like family
SMART SM01226 GAGA_bind_2
MobiDBLite mobidb-lite consensus disorder prediction
Coils Coil Coil
PANTHER PTHR31421 -
MapolyID Mapoly0018s0011 -

Nomenclature

Gene symbol Product Transcript ID Status
MpBPCU transcription factor, BBR/BPC Published

Associated Literature (AI-based literature mining, Beta-version)

A U chromosome-linked BASIC PENTACYSTEINE transcription factor gene identified as the master sex determinant ("Feminizer") in M. polymorpha. Two independent bpcU mutants formed male sex organs, showing BPCU is necessary and sufficient for female sex determination. It acts by directly regulating the autosomal FGMYB/SUF locus, repressing the SUF lncRNA via chromatin modification.

2 core 7 peripheral

Fu, Y., et al. (2025) · Journal of Integrative Plant Biology: doi: 10.1111/jipb.13867  research experimental subject
The feminizer master regulator (= MpUg00370), encoding a BASIC PENTACYSTEINE transcription factor. BLASTP searches showed the ortholog is retained in monoicous R. natans but relocated to autosomal chromosome 1, while R. cavernosa and R. fluitans lack BPCU orthologs. This indicates a different system not involving feminizer and suppressor evolved in some species.
Iwasaki, M., et al. (2021a) · Current Biology  research experimental subject
A U chromosome-linked BASIC PENTACYSTEINE transcription factor gene identified as the master sex determinant ("Feminizer") in M. polymorpha. Two independent bpcU mutants formed male sex organs, showing BPCU is necessary and sufficient for female sex determination. It acts by directly regulating the autosomal FGMYB/SUF locus, repressing the SUF lncRNA via chromatin modification.
Ekwealor, J. T. B., et al. (2023) · Current Biology  research citation background
Current Biology dispatch: cites the U-linked feminizing gene MpUg00370 among six ancestral U-linked genes now dispersed across autosomes, discussing cosexuality evolution.
Levins, J., et al. (2025) · New Phytologist 10.1111/nph.20454  research citation comparator
Cited as the Marchantia U-linked feminizer (BPC on U) promoting female development via suppression of MpSUF; used as comparator, ortholog reported missing in Riccia.
Kajiwara, T., et al. (2024) · Plant & Cell Physiology  research citation background
U-chromosome gene that, per prior work, binds the SUF locus and represses it via chromatin modification, relieving FGMYB to determine feminization.

Expression Level powered by MBEX

Link to the original image in MBEX

Transcript models

Transcript ID Location Sequences Extract region
MpUg00370.1 chrU:4472706..4474835 (-) Gene /  mRNA /  CDS /  Protein
FASTA / GenBank (with flanking bases)
MpUg00370.2 chrU:4472701..4474509 (-) Gene /  mRNA /  CDS /  Protein
FASTA / GenBank (with flanking bases)

Gene structure:

Sequences:

Gene UTR + CDS + intron

FASTA

mRNA UTR + CDS

FASTA

CDS

FASTA

Protein

FASTA

Gene structure:

Sequences:

Gene UTR + CDS + intron

FASTA

mRNA UTR + CDS

FASTA

CDS

FASTA

Protein

FASTA


MarpolBase / Genome Informatics Lab. NIG.