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MpPUB9, a U-box E3 ubiquitin ligase, acts as a positive regulator by promoting the turnover of MpEXO70.1 under high salinity in Marchantia polymorpha.

Lim, C. J., et al. · 2024 · New Phytologist   research

doi:10.1111/nph.20169   PMID:39387122   PMC11579444

Linked genes (15)  4 core 11 peripheral

Gene ID Name Evidence / Role Function (this paper)
Mp5g19550 MpEXO70.1 missing experimental subject Identified as the direct substrate of MpPUB9 among exocyst paralogs. MpPUB9 interacts with and ubiquitinates MpEXO70.1, promoting its turnover; protein stability measured under salt stress and overexpression lines analyzed.
MpPUB10 missing experimental subject Closely related U-box gene functionally tested for contrast: gain/loss-of-function mutants showed no prominent thallus growth-angle phenotype and the protein did not interact with EXO70 paralogs in yeast, underscoring MpPUB9's specificity.
MpPUB24 missing experimental subject Studied U-box ligase (= MpNOP1/NOPPERABO1) shown to retain intact enzyme activity; used in functional/sequence comparison of the U-box domain to characterize the MpPUB family.
MpPUB9 missing experimental subject Central subject: U-box E3 ubiquitin ligase rapidly induced by high salinity and dehydration. Gain/loss-of-function mutants and overexpressors made; in vitro E3 ligase activity confirmed. Acts as positive regulator of salt tolerance by ubiquitinating and promoting turnover of MpEXO70.1.
MpCPS missing citation comparator Cited as required for far-red-induced hyponastic growth; expression unchanged in MpPUB9 overexpressors.
Mp1g14780 MpEXO70.2 missing experimental comparator Exocyst paralog (Mp1g14780) tested as comparator; no interaction with MpPUB9 detected and localization examined.
Mp1g02880 MpEXO70.3 missing experimental comparator Exocyst paralog (Mp1g02880) tested as comparator; interacted only very weakly with MpPUB9 in yeast.
Mp2g11710 MpKAI2A citation comparator Karrikin-signaling gene cited; loss-of-function causes curved upward growth; expression unchanged in MpPUB9 lines.
Mp2g04930 MpKAI2B citation comparator Karrikin-signaling gene cited alongside MpKAI2A; expression unchanged in MpPUB9 overexpressors.
Mp1g02580 MpMAX2 citation comparator Karrikin-signaling gene cited with MpKAI2A/B; expression unaltered in MpPUB9 lines.
Mp5g05140 MpPIN2 citation comparator Auxin transporter cited as affecting thallus growth angle; its expression not significantly changed in MpPUB9 overexpressors.
MpUBQ10 missing experimental tool Used as the reference/normalization gene for qRT-PCR of MpPUB9 expression.
Mp4g08580 missing sequence background Added to the list of putative MpPUB genes based on sequence conservation.
Mp5g12010 MpCOP1 citation background RING-type E3 ligase (Mp5g12010) cited and excluded from the PUB protein classification.
Mp8g11800 MpNOP1 citation background Alternative name for MpPUB24/NOPPERABO1, previously reported to control formation of intercellular spaces.